1yhn

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[[Image:1yhn.gif|left|200px]]
[[Image:1yhn.gif|left|200px]]
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{{Structure
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|PDB= 1yhn |SIZE=350|CAPTION= <scene name='initialview01'>1yhn</scene>, resolution 3.&Aring;
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The line below this paragraph, containing "STRUCTURE_1yhn", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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|GENE= Rab7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RILP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1yhn| PDB=1yhn | SCENE= }}
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|RELATEDENTRY=[[1t91|1T91]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yhn OCA], [http://www.ebi.ac.uk/pdbsum/1yhn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yhn RCSB]</span>
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'''Structure basis of RILP recruitment by Rab7'''
'''Structure basis of RILP recruitment by Rab7'''
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[[Category: Wang, T.]]
[[Category: Wang, T.]]
[[Category: Wu, M.]]
[[Category: Wu, M.]]
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[[Category: protein transport]]
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[[Category: Protein transport]]
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[[Category: rab7]]
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[[Category: Rab7]]
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[[Category: rilp]]
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[[Category: Rilp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:19:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:07:33 2008''
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Revision as of 13:19, 3 May 2008

Image:1yhn.gif

Template:STRUCTURE 1yhn

Structure basis of RILP recruitment by Rab7


Overview

Rab7 regulates vesicle traffic from early to late endosomes, and from late endosomes to lysosomes. The crystal structure of Rab7-GTP in complex with the Rab7 binding domain of RILP reveals that Rab7 interacts with RILP specifically via two distinct areas, with the first one involving the switch and interswitch regions and the second one consisting of RabSF1 and RabSF4. Disruption of these interactions by mutations abrogates late endosomal/lysosomal targeting of Rab7 and RILP. The Rab7 binding domain of RILP forms a coiled-coil homodimer with two symmetric surfaces to interact with two separate Rab7-GTP molecules, forming a dyad configuration of Rab7-RILP(2)-Rab7. Mutations that disrupt RILP dimerization also abolish its interactions with Rab7-GTP and late endosomal/lysosomal targeting, suggesting that the dimeric form of RILP is a functional unit. Structural comparison suggests that the combined use of RabSF1 and RabSF4 with the switch regions may be a general mode of action for most Rab proteins in regulating membrane trafficking.

About this Structure

1YHN is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recruitment of RILP by small GTPase Rab7., Wu M, Wang T, Loh E, Hong W, Song H, EMBO J. 2005 Apr 20;24(8):1491-501. Epub 2005 Mar 31. PMID:15933719 Page seeded by OCA on Sat May 3 16:19:35 2008

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