1yia

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[[Image:1yia.gif|left|200px]]
[[Image:1yia.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1yia |SIZE=350|CAPTION= <scene name='initialview01'>1yia</scene>, resolution 3.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1yia", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HRP:5-HYDROXY-L-TRYPTOPHAN'>HRP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan--tRNA_ligase Tryptophan--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.2 6.1.1.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= DR1093 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 Deinococcus radiodurans R1])
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-->
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|DOMAIN=
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{{STRUCTURE_1yia| PDB=1yia | SCENE= }}
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|RELATEDENTRY=[[1yi8|1YI8]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yia OCA], [http://www.ebi.ac.uk/pdbsum/1yia PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yia RCSB]</span>
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}}
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'''Crystal structure of tryptophanyl tRNA synthetase II from Deinococcus radiodurans in complex with 5-Hydroxy tryptophan.'''
'''Crystal structure of tryptophanyl tRNA synthetase II from Deinococcus radiodurans in complex with 5-Hydroxy tryptophan.'''
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[[Category: Crane, B R.]]
[[Category: Crane, B R.]]
[[Category: 5 hydroxy tryptophan]]
[[Category: 5 hydroxy tryptophan]]
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[[Category: trna synthetase]]
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[[Category: Trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:21:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:08:24 2008''
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Revision as of 13:21, 3 May 2008

Image:1yia.gif

Template:STRUCTURE 1yia

Crystal structure of tryptophanyl tRNA synthetase II from Deinococcus radiodurans in complex with 5-Hydroxy tryptophan.


Overview

The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found in Deinococcus radiodurans interacts with a nitric oxide synthase protein that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal structures of TrpRS II bound to tryptophan and 5-HRP reveal residue substitutions that accommodate modified indoles. A class of auxiliary bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard amino acids.

About this Structure

1YIA is a Single protein structure of sequence from Deinococcus radiodurans r1. Full crystallographic information is available from OCA.

Reference

Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan., Buddha MR, Crane BR, Nat Struct Mol Biol. 2005 Mar;12(3):274-5. Epub 2005 Feb 20. PMID:15723076 Page seeded by OCA on Sat May 3 16:21:12 2008

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