1yjo
From Proteopedia
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[[Image:1yjo.gif|left|200px]] | [[Image:1yjo.gif|left|200px]] | ||
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'''Structure of NNQQNY from yeast prion Sup35 with zinc acetate''' | '''Structure of NNQQNY from yeast prion Sup35 with zinc acetate''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1YJO is a [[Single protein]] structure | + | 1YJO is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Riekel, C.]] | [[Category: Riekel, C.]] | ||
[[Category: Sawaya, M R.]] | [[Category: Sawaya, M R.]] | ||
| - | [[Category: | + | [[Category: Asparagine zipper]] |
| - | [[Category: | + | [[Category: Glutamine zipper]] |
| - | [[Category: | + | [[Category: Keywords beta sheet]] |
| - | [[Category: | + | [[Category: Steric zipper]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:24:23 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:24, 3 May 2008
Structure of NNQQNY from yeast prion Sup35 with zinc acetate
Overview
Numerous soluble proteins convert to insoluble amyloid-like fibrils that have common properties. Amyloid fibrils are associated with fatal diseases such as Alzheimer's, and amyloid-like fibrils can be formed in vitro. For the yeast protein Sup35, conversion to amyloid-like fibrils is associated with a transmissible infection akin to that caused by mammalian prions. A seven-residue peptide segment from Sup35 forms amyloid-like fibrils and closely related microcrystals, from which we have determined the atomic structure of the cross-beta spine. It is a double beta-sheet, with each sheet formed from parallel segments stacked in register. Side chains protruding from the two sheets form a dry, tightly self-complementing steric zipper, bonding the sheets. Within each sheet, every segment is bound to its two neighbouring segments through stacks of both backbone and side-chain hydrogen bonds. The structure illuminates the stability of amyloid fibrils, their self-seeding characteristic and their tendency to form polymorphic structures.
About this Structure
1YJO is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Structure of the cross-beta spine of amyloid-like fibrils., Nelson R, Sawaya MR, Balbirnie M, Madsen AO, Riekel C, Grothe R, Eisenberg D, Nature. 2005 Jun 9;435(7043):773-8. PMID:15944695 Page seeded by OCA on Sat May 3 16:24:23 2008
