1ymm
From Proteopedia
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[[Image:1ymm.gif|left|200px]] | [[Image:1ymm.gif|left|200px]] | ||
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'''TCR/HLA-DR2b/MBP-peptide complex''' | '''TCR/HLA-DR2b/MBP-peptide complex''' | ||
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[[Category: Pyrdol, J.]] | [[Category: Pyrdol, J.]] | ||
[[Category: Wucherpfennig, K W.]] | [[Category: Wucherpfennig, K W.]] | ||
| - | [[Category: | + | [[Category: Auto-immunity]] |
| - | [[Category: | + | [[Category: Protein-protein complex]] |
| - | [[Category: | + | [[Category: T cell repertoire]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:30:49 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:30, 3 May 2008
TCR/HLA-DR2b/MBP-peptide complex
Overview
Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topology notably different from that of antimicrobial TCRs. Rather than being centered on the peptide-major histocompatibility complex, this TCR contacted only the N-terminal peptide segment and made asymmetrical interactions with the major histocompatibility complex helices. The interaction was dominated by the hypervariable complementarity-determining region 3 loops, indicating that unconventional topologies are possible because of the unique complementarity-determining region 3 sequences created during rearrangement. This topology reduces the interaction surface with peptide and alters the geometry for CD4 association. We propose that unusual TCR-binding properties can permit autoreactive T cells to escape deletion.
About this Structure
1YMM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor., Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW, Nat Immunol. 2005 May;6(5):490-6. Epub 2005 Apr 10. PMID:15821740 Page seeded by OCA on Sat May 3 16:30:49 2008
