1yop

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[[Image:1yop.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1yop", creates the "Structure Box" on the page.
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yop FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yop OCA], [http://www.ebi.ac.uk/pdbsum/1yop PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yop RCSB]</span>
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'''The solution structure of Kti11p'''
'''The solution structure of Kti11p'''
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[[Category: Zhao, W.]]
[[Category: Zhao, W.]]
[[Category: Zhou, C Z.]]
[[Category: Zhou, C Z.]]
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[[Category: zinc finger]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:35:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:16:09 2008''
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Revision as of 13:35, 3 May 2008

Image:1yop.gif

Template:STRUCTURE 1yop

The solution structure of Kti11p


Overview

Kti11p is a small, highly conserved CSL zinc finger-containing protein found in many eukaryotes. It was first identified as one of the factors required for maintaining the sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin. Then, it was found to be identical to Dph3, a protein required for diphthamide biosynthesis on eEF-2, the target of diphtheria toxin and Pseudomonas exotoxin A, in both yeast and higher eukaryotes. Furthermore, Kti11p/Dph3 was found to physically interact with core-Elongator, ribosomal proteins, eEF-2, two other proteins required for diphthamide modification on eEF-2, and DelGEF. Here, we determined the solution structure of Kti11p using NMR, providing the first structure of the CSL-class zinc-binding protein family. We present the first experimental evidence that Kti11p can bind a single Zn(2+) ion by its four conserved cysteine residues. The major structure of Kti11p comprises a beta sandwich as well as an alpha helix. Moreover, a structure-based similarity search suggests that it represents a novel structure and may define a new family of the zinc ribbon fold group. Therefore, our work provides a molecular basis for further understanding the multiple functions of Kti11p/Dph3 in different biological processes.

About this Structure

1YOP is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module., Sun J, Zhang J, Wu F, Xu C, Li S, Zhao W, Wu Z, Wu J, Zhou CZ, Shi Y, Biochemistry. 2005 Jun 21;44(24):8801-9. PMID:15952786 Page seeded by OCA on Sat May 3 16:35:38 2008

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