1yqs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1yqs.gif|left|200px]]
[[Image:1yqs.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1yqs |SIZE=350|CAPTION= <scene name='initialview01'>1yqs</scene>, resolution 1.05&Aring;
+
The line below this paragraph, containing "STRUCTURE_1yqs", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BSA:2-(BENZOYLAMINO)ETHANESULFONIC+ACID'>BSA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Serine-type_D-Ala-D-Ala_carboxypeptidase Serine-type D-Ala-D-Ala carboxypeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.16.4 3.4.16.4] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1yqs| PDB=1yqs | SCENE= }}
-
|RELATEDENTRY=[[1scw|1SCW]], [[1sde|1SDE]], [[1mpl|1MPL]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yqs OCA], [http://www.ebi.ac.uk/pdbsum/1yqs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yqs RCSB]</span>
+
-
}}
+
'''Inhibition of the R61 DD-Peptidase by N-benzoyl-beta-sultam'''
'''Inhibition of the R61 DD-Peptidase by N-benzoyl-beta-sultam'''
Line 33: Line 30:
[[Category: Page, M I.]]
[[Category: Page, M I.]]
[[Category: Silvaggi, N R.]]
[[Category: Silvaggi, N R.]]
-
[[Category: beta-lactam]]
+
[[Category: Beta-lactam]]
-
[[Category: beta-sultam]]
+
[[Category: Beta-sultam]]
-
[[Category: cell well biosynthesis]]
+
[[Category: Cell well biosynthesis]]
-
[[Category: peptidase]]
+
[[Category: Peptidase]]
-
[[Category: sulfonylation]]
+
[[Category: Sulfonylation]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:39:53 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:18:19 2008''
+

Revision as of 13:39, 3 May 2008

Image:1yqs.gif

Template:STRUCTURE 1yqs

Inhibition of the R61 DD-Peptidase by N-benzoyl-beta-sultam


Overview

N-Acyl-beta-sultams are time-dependent, irreversible active site-directed inhibitors of Streptomyces R61 DD-peptidase. The rate of inactivation is first order with respect to beta-sultam concentration, and the second-order rate constants show a dependence on pH similar to that for the hydrolysis of a substrate. Inactivation is due to the formation of a stable 1:1 enzyme-inhibitor complex as a result of the active site serine being sulfonylated by the beta-sultam as shown by ESI-MS analysis and by X-ray crystallography. A striking feature of the sulfonyl enzyme is that the inhibitor is not bound to the oxyanion hole but interacts extensively with the "roof" of the active site where the Arg 285 is located.

About this Structure

1YQS is a Single protein structure of sequence from Streptomyces sp.. Full crystallographic information is available from OCA.

Reference

Inactivation of bacterial DD-peptidase by beta-sultams., Llinas A, Ahmed N, Cordaro M, Laws AP, Frere JM, Delmarcelle M, Silvaggi NR, Kelly JA, Page MI, Biochemistry. 2005 May 31;44(21):7738-46. PMID:15909988 Page seeded by OCA on Sat May 3 16:39:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1yqs"
Personal tools