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1yrx

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[[Image:1yrx.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=D9G:N-DODECYL-N,N-DIMETHYLGLYCINATE'>D9G</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yrx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yrx OCA], [http://www.ebi.ac.uk/pdbsum/1yrx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yrx RCSB]</span>
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'''Structure of a novel photoreceptor: the BLUF domain of AppA from Rhodobacter sphaeroides'''
'''Structure of a novel photoreceptor: the BLUF domain of AppA from Rhodobacter sphaeroides'''
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[[Category: Moffat, K.]]
[[Category: Moffat, K.]]
[[Category: Ybe, J.]]
[[Category: Ybe, J.]]
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[[Category: ferredoxin-like fold]]
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[[Category: Ferredoxin-like fold]]
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[[Category: flavin binding]]
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[[Category: Flavin binding]]
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[[Category: photoreceptor]]
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[[Category: Photoreceptor]]
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Revision as of 13:42, 3 May 2008

Image:1yrx.gif

Template:STRUCTURE 1yrx

Structure of a novel photoreceptor: the BLUF domain of AppA from Rhodobacter sphaeroides


Overview

The flavin-binding BLUF domain of AppA represents a new class of blue light photoreceptors that are present in a number of bacterial and algal species. The dark state X-ray structure of this domain was determined at 2.3 A resolution. The domain demonstrates a new function for the common ferredoxin-like fold; two long alpha-helices flank the flavin, which is bound with its isoalloxazine ring perpendicular to a five-stranded beta-sheet. The hydrogen bond network and the overall protein topology of the BLUF domain (but not its sequence) bear some resemblance to LOV domains, a subset of PAS domains widely involved in signaling. Nearly all residues conserved in BLUF domains surround the flavin chromophore, many of which are involved in an intricate hydrogen bond network. Photoactivation may induce a rearrangement in this network via reorientation of the Gln63 side chain to form a new hydrogen bond to the flavin O4 position. This shift would also break a hydrogen bond to the Trp104 side chain, which may be critical in induction of global structural change in AppA.

About this Structure

1YRX is a Single protein structure of sequence from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

Reference

Structure of a novel photoreceptor, the BLUF domain of AppA from Rhodobacter sphaeroides., Anderson S, Dragnea V, Masuda S, Ybe J, Moffat K, Bauer C, Biochemistry. 2005 Jun 7;44(22):7998-8005. PMID:15924418 Page seeded by OCA on Sat May 3 16:42:28 2008

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