1ys5
From Proteopedia
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'''Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis''' | '''Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis''' | ||
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[[Category: Swennen, E.]] | [[Category: Swennen, E.]] | ||
[[Category: Veggi, D.]] | [[Category: Veggi, D.]] | ||
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| - | [[Category: | + | [[Category: Neisseria meningitidi]] |
| - | [[Category: | + | [[Category: Vaccine candidate]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:42:54 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:42, 3 May 2008
Solution structure of the antigenic domain of GNA1870 of Neisseria meningitidis
Overview
GNA1870, a 28-kDa surface-exposed lipoprotein of Neisseria meningitidis recently discovered by reverse vaccinology, is one of the most potent antigens of Meningococcus and a promising candidate for a universal vaccine against a devastating disease. Previous studies of epitope mapping and genetic characterization identified residues critical for bactericidal response within the C-terminal domain of the molecule. To elucidate the conformation of protective epitopes, we used NMR spectroscopy to obtain the solution structure of the immunodominant 18-kDa C-terminal portion of GNA1870. The structure consists of an eight-stranded antiparallel beta-barrel overlaid by a short alpha-helix with an unstructured N-terminal end. Residues previously shown to be important for antibody recognition were mapped on loops facing the same ridge of the molecule. The sequence similarity of GNA1870 with members of the bacterial transferrin receptor family allows one to predict the folding of this class of well known bacterial antigens, providing the basis for the rational engineering of high affinity B cell epitopes.
About this Structure
1YS5 is a Single protein structure of sequence from Neisseria meningitidis. Full crystallographic information is available from OCA.
Reference
Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis., Cantini F, Savino S, Scarselli M, Masignani V, Pizza M, Romagnoli G, Swennen E, Veggi D, Banci L, Rappuoli R, J Biol Chem. 2006 Mar 17;281(11):7220-7. Epub 2005 Dec 31. PMID:16407174 Page seeded by OCA on Sat May 3 16:42:54 2008
