1ysv

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[[Image:1ysv.gif|left|200px]]
[[Image:1ysv.gif|left|200px]]
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{{Structure
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|PDB= 1ysv |SIZE=350|CAPTION= <scene name='initialview01'>1ysv</scene>
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The line below this paragraph, containing "STRUCTURE_1ysv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1ysv| PDB=1ysv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ysv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ysv OCA], [http://www.ebi.ac.uk/pdbsum/1ysv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ysv RCSB]</span>
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'''Solution structure of the central region of the human GluR-B R/G pre-mRNA'''
'''Solution structure of the central region of the human GluR-B R/G pre-mRNA'''
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==About this Structure==
==About this Structure==
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1YSV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
==Reference==
==Reference==
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15840813 15840813]
A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15840813 15840813]
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[[Category: Protein complex]]
 
[[Category: Allain, F H.]]
[[Category: Allain, F H.]]
[[Category: Stefl, R.]]
[[Category: Stefl, R.]]
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[[Category: adar2]]
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[[Category: Adar2]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: pentaloop]]
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[[Category: Pentaloop]]
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[[Category: rna]]
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[[Category: Rna]]
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[[Category: rna editing]]
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[[Category: Rna editing]]
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[[Category: stem-loop]]
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[[Category: Stem-loop]]
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[[Category: structure]]
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[[Category: Structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:44:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:20:49 2008''
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Revision as of 13:44, 3 May 2008

Image:1ysv.gif

Template:STRUCTURE 1ysv

Solution structure of the central region of the human GluR-B R/G pre-mRNA


Overview

Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.

About this Structure

Full crystallographic information is available from OCA.

Reference

A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:15840813 Page seeded by OCA on Sat May 3 16:44:38 2008

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OCA

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