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1ytv
From Proteopedia
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[[Image:1ytv.gif|left|200px]] | [[Image:1ytv.gif|left|200px]] | ||
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'''Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor''' | '''Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor''' | ||
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[[Category: Wu, N.]] | [[Category: Wu, N.]] | ||
[[Category: Xu, Z.]] | [[Category: Xu, Z.]] | ||
| - | [[Category: | + | [[Category: Fusion protein]] |
| - | [[Category: | + | [[Category: Gpcr]] |
| - | [[Category: | + | [[Category: Maltose-binding protein]] |
| - | [[Category: | + | [[Category: Receptor]] |
| - | [[Category: | + | [[Category: Vasopressin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:47:01 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 13:47, 3 May 2008
Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor
Overview
The V1 vascular vasopressin receptor (V1R) is a G-protein-coupled receptor (GPCR) involved in the regulation of body-fluid osmolality, blood volume and blood pressure. Signal transduction is mediated by the third intracellular loop of this seven-transmembrane protein as well as by the C-terminal cytoplasmic segment. A chimera of the maltose-binding protein (MBP) and the C-terminal segment of V1R has been cloned, expressed, purified and crystallized. The crystals belong to space group P2(1), with unit-cell parameters a = 51.10, b = 66.56, c = 115.72 A, beta = 95.99 degrees. The 1.8 A crystal structure reveals the conformation of MBP and part of the linker region of this chimera, with the C-terminal segment being unstructured. This may reflect a conformational plasticity in the C-terminal segment that may be necessary for proper function of V1R.
About this Structure
1YTV is a Protein complex structure of sequences from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA.
Reference
A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein., Adikesavan NV, Mahmood SS, Stanley N, Xu Z, Wu N, Thibonnier M, Shoham M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt, 4):341-5. Epub 2005 Mar 24. PMID:16511036 Page seeded by OCA on Sat May 3 16:47:01 2008
