1ytv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ytv.gif|left|200px]]
[[Image:1ytv.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ytv |SIZE=350|CAPTION= <scene name='initialview01'>1ytv</scene>, resolution 1.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ytv", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= malE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), AVPR1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ytv| PDB=1ytv | SCENE= }}
-
|RELATEDENTRY=[[1a7l|1A7L]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ytv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ytv OCA], [http://www.ebi.ac.uk/pdbsum/1ytv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ytv RCSB]</span>
+
-
}}
+
'''Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor'''
'''Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor'''
Line 33: Line 30:
[[Category: Wu, N.]]
[[Category: Wu, N.]]
[[Category: Xu, Z.]]
[[Category: Xu, Z.]]
-
[[Category: fusion protein]]
+
[[Category: Fusion protein]]
-
[[Category: gpcr]]
+
[[Category: Gpcr]]
-
[[Category: maltose-binding protein]]
+
[[Category: Maltose-binding protein]]
-
[[Category: receptor]]
+
[[Category: Receptor]]
-
[[Category: vasopressin]]
+
[[Category: Vasopressin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:47:01 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:22:06 2008''
+

Revision as of 13:47, 3 May 2008

Image:1ytv.gif

Template:STRUCTURE 1ytv

Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor


Overview

The V1 vascular vasopressin receptor (V1R) is a G-protein-coupled receptor (GPCR) involved in the regulation of body-fluid osmolality, blood volume and blood pressure. Signal transduction is mediated by the third intracellular loop of this seven-transmembrane protein as well as by the C-terminal cytoplasmic segment. A chimera of the maltose-binding protein (MBP) and the C-terminal segment of V1R has been cloned, expressed, purified and crystallized. The crystals belong to space group P2(1), with unit-cell parameters a = 51.10, b = 66.56, c = 115.72 A, beta = 95.99 degrees. The 1.8 A crystal structure reveals the conformation of MBP and part of the linker region of this chimera, with the C-terminal segment being unstructured. This may reflect a conformational plasticity in the C-terminal segment that may be necessary for proper function of V1R.

About this Structure

1YTV is a Protein complex structure of sequences from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA.

Reference

A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein., Adikesavan NV, Mahmood SS, Stanley N, Xu Z, Wu N, Thibonnier M, Shoham M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt, 4):341-5. Epub 2005 Mar 24. PMID:16511036 Page seeded by OCA on Sat May 3 16:47:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ytv"
Personal tools