1yuj

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[[Image:1yuj.gif|left|200px]]
[[Image:1yuj.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1yuj", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1yuj| PDB=1yuj | SCENE= }}
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|RELATEDENTRY=[[1yui|1YUI]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yuj OCA], [http://www.ebi.ac.uk/pdbsum/1yuj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yuj RCSB]</span>
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'''SOLUTION NMR STRUCTURE OF THE GAGA FACTOR/DNA COMPLEX, 50 STRUCTURES'''
'''SOLUTION NMR STRUCTURE OF THE GAGA FACTOR/DNA COMPLEX, 50 STRUCTURES'''
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[[Category: Gronenborn, A M.]]
[[Category: Gronenborn, A M.]]
[[Category: Omichinski, J G.]]
[[Category: Omichinski, J G.]]
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[[Category: chromatin remodeling]]
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[[Category: Chromatin remodeling]]
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[[Category: complex (dna-binding protein/dna)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:48:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:23:05 2008''
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Revision as of 13:48, 3 May 2008

Image:1yuj.gif

Template:STRUCTURE 1yuj

SOLUTION NMR STRUCTURE OF THE GAGA FACTOR/DNA COMPLEX, 50 STRUCTURES


Overview

The structure of a complex between the DNA binding domain of the GAGA factor (GAGA-DBD) and an oligonucleotide containing its GAGAG consensus binding site has been determined by nuclear magnetic resonance spectroscopy. The GAGA-DBD comprises a single classical Cys2-His2 zinc finger core, and an N-terminal extension containing two highly basic regions, BR1 and BR2. The zinc finger core binds in the major groove and recognizes the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. Unlike the latter, which require tandem zinc finger repeats with a minimum of two units for high affinity binding, the GAGA-DBD makes use of only a single finger complemented by BR1 and BR2. BR2 forms a helix that interacts in the major groove recognizing the last G of the consensus, while BR1 wraps around the DNA in the minor groove and recognizes the A in the fourth position of the consensus. The implications of the structure of the GAGA-DBD-DNA complex for chromatin remodelling are discussed.

About this Structure

1YUJ is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode., Omichinski JG, Pedone PV, Felsenfeld G, Gronenborn AM, Clore GM, Nat Struct Biol. 1997 Feb;4(2):122-32. PMID:9033593 Page seeded by OCA on Sat May 3 16:48:32 2008

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