1yux

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[[Image:1yux.gif|left|200px]]
[[Image:1yux.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1yux |SIZE=350|CAPTION= <scene name='initialview01'>1yux</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1yux", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= ngr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=881 Desulfovibrio vulgaris])
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-->
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|DOMAIN=
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{{STRUCTURE_1yux| PDB=1yux | SCENE= }}
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|RELATEDENTRY=[[1yuz|1YUZ]], [[1yu1|1YU1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yux OCA], [http://www.ebi.ac.uk/pdbsum/1yux PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yux RCSB]</span>
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}}
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'''Mixed valant state of nigerythrin'''
'''Mixed valant state of nigerythrin'''
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[[Category: Lanzilotta, W N.]]
[[Category: Lanzilotta, W N.]]
[[Category: Silaghi-Dumitrescu, R.]]
[[Category: Silaghi-Dumitrescu, R.]]
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[[Category: diiron]]
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[[Category: Diiron]]
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[[Category: electron transfer]]
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[[Category: Electron transfer]]
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[[Category: hemerythrin]]
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[[Category: Hemerythrin]]
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[[Category: peroxidase]]
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[[Category: Peroxidase]]
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[[Category: rubredoxin]]
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[[Category: Rubredoxin]]
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[[Category: rubrythrin]]
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[[Category: Rubrythrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:49:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:23:23 2008''
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Revision as of 13:49, 3 May 2008

Image:1yux.gif

Template:STRUCTURE 1yux

Mixed valant state of nigerythrin


Overview

High-resolution crystal structures of Desulfovibrio vulgaris nigerythrin (DvNgr), a member of the rubrerythrin (Rbr) family, demonstrate an approximately 2-A movement of one iron (Fe1) of the diiron site from a carboxylate to a histidine ligand upon conversion of the mixed-valent ([Fe2(II),Fe1(III)]) to diferrous states, even at cryogenic temperatures. This Glu<-->His ligand "toggling" of one iron, which also occurs in DvRbr, thus, appears to be a characteristic feature of Rbr-type diiron sites. Unique features of DvNgr revealed by these structures include redox-induced flipping of a peptide carbonyl that reversibly forms a hydrogen bond to the histidine ligand to Fe1 of the diiron site, an intra-subunit proximal orientation of the rubredoxin-(Rub)-like and diiron domains, and an electron transfer pathway consisting of six covalent and two hydrogen bonds connecting the Rub-like iron with Fe2 of the diiron site. This pathway can account for DvNgr's relatively rapid peroxidase turnover. The characteristic combination of iron sites together with the redox-dependent iron toggling between protein ligands can account for the selectivity of Rbrs for hydrogen peroxide over dioxygen.

About this Structure

1YUX is a Single protein structure of sequence from Desulfovibrio vulgaris. Full crystallographic information is available from OCA.

Reference

High-resolution crystal structures of Desulfovibrio vulgaris (Hildenborough) nigerythrin: facile, redox-dependent iron movement, domain interface variability, and peroxidase activity in the rubrerythrins., Iyer RB, Silaghi-Dumitrescu R, Kurtz DM Jr, Lanzilotta WN, J Biol Inorg Chem. 2005 Jun;10(4):407-16. Epub 2005 May 14. PMID:15895271 Page seeded by OCA on Sat May 3 16:49:11 2008

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OCA

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