1yv3

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[[Image:1yv3.gif|left|200px]]
[[Image:1yv3.gif|left|200px]]
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{{Structure
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|PDB= 1yv3 |SIZE=350|CAPTION= <scene name='initialview01'>1yv3</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1yv3", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BIT:(-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE'>BIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1yv3| PDB=1yv3 | SCENE= }}
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|RELATEDENTRY=[[1vom|1VOM]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yv3 OCA], [http://www.ebi.ac.uk/pdbsum/1yv3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1yv3 RCSB]</span>
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'''The structural basis of blebbistatin inhibition and specificity for myosin II'''
'''The structural basis of blebbistatin inhibition and specificity for myosin II'''
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[[Category: Rayment, I.]]
[[Category: Rayment, I.]]
[[Category: Smith, R.]]
[[Category: Smith, R.]]
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[[Category: blebbistatin]]
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[[Category: Blebbistatin]]
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[[Category: metastable state]]
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[[Category: Metastable state]]
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[[Category: myosin]]
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[[Category: Myosin]]
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[[Category: myosin ii inhibitor]]
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[[Category: Myosin ii inhibitor]]
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[[Category: myosin-inhibitor complex]]
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[[Category: Myosin-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:49:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:23:38 2008''
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Revision as of 13:49, 3 May 2008

Image:1yv3.gif

Template:STRUCTURE 1yv3

The structural basis of blebbistatin inhibition and specificity for myosin II


Overview

Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.

About this Structure

1YV3 is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:15750603 Page seeded by OCA on Sat May 3 16:49:33 2008

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