1ywg
From Proteopedia
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[[Image:1ywg.gif|left|200px]] | [[Image:1ywg.gif|left|200px]] | ||
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'''The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum''' | '''The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum''' | ||
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==Reference== | ==Reference== | ||
Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum., Satchell JF, Malby RL, Luo CS, Adisa A, Alpyurek AE, Klonis N, Smith BJ, Tilley L, Colman PM, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1213-21. Epub 2005, Aug 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16131754 16131754] | Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum., Satchell JF, Malby RL, Luo CS, Adisa A, Alpyurek AE, Klonis N, Smith BJ, Tilley L, Colman PM, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1213-21. Epub 2005, Aug 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16131754 16131754] | ||
| - | [[Category: Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)]] | ||
[[Category: Plasmodium falciparum]] | [[Category: Plasmodium falciparum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Satchell, J F.]] | [[Category: Satchell, J F.]] | ||
[[Category: Tilley, L.]] | [[Category: Tilley, L.]] | ||
| - | [[Category: | + | [[Category: Dehydrogenase]] |
| - | [[Category: | + | [[Category: Rossman fold]] |
| - | [[Category: | + | [[Category: Tetrameric]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:52:53 2008'' | |
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Revision as of 13:52, 3 May 2008
The structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum
Overview
The malaria parasite Plasmodium falciparum is responsible for about two million deaths annually, making it important to obtain information about enzymes from this organism that represent potential drug targets. The gene for P. falciparum glyceraldehyde-3-phosphate dehydrogenase (PfGAPDH) has been cloned and the protein expressed as a hexahistidine-tagged recombinant protein in Escherichia coli. The recombinant protein has been crystallized and its three-dimensional structure determined. One molecule of the cofactor NAD+ is bound to each of the four subunits in the tetrameric enzyme. The major structural feature distinguishing human GAPDH from PfGAPDH is the insertion of a dipeptide (-KG-) in the so-called S loop. This insert, together with other characteristic single-amino-acid substitutions, alters the chemical environment of the groove that encompasses the R dyad and that links adjacent cofactor-binding sites and may be responsible for the selective inhibition of the enzyme by ferriprotoporphyrin IX.
About this Structure
1YWG is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
Reference
Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum., Satchell JF, Malby RL, Luo CS, Adisa A, Alpyurek AE, Klonis N, Smith BJ, Tilley L, Colman PM, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1213-21. Epub 2005, Aug 16. PMID:16131754 Page seeded by OCA on Sat May 3 16:52:53 2008
