1z01

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1z01.gif|left|200px]]
[[Image:1z01.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1z01 |SIZE=350|CAPTION= <scene name='initialview01'>1z01</scene>, resolution 1.8&Aring;
+
The line below this paragraph, containing "STRUCTURE_1z01", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/2-hydroxyquinoline_8-monooxygenase 2-hydroxyquinoline 8-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.61 1.14.13.61] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1z01| PDB=1z01 | SCENE= }}
-
|RELATEDENTRY=[[1z02|1Z02]], [[1z03|1Z03]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z01 OCA], [http://www.ebi.ac.uk/pdbsum/1z01 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z01 RCSB]</span>
+
-
}}
+
'''2-Oxoquinoline 8-Monooxygenase Component: Active site Modulation by Rieske-[2fe-2S] Center Oxidation/Reduction'''
'''2-Oxoquinoline 8-Monooxygenase Component: Active site Modulation by Rieske-[2fe-2S] Center Oxidation/Reduction'''
Line 29: Line 26:
[[Category: Martins, B M.]]
[[Category: Martins, B M.]]
[[Category: Svetlitchnaia, T.]]
[[Category: Svetlitchnaia, T.]]
-
[[Category: monooxygenase]]
+
[[Category: Monooxygenase]]
-
[[Category: oxygen binding/activation]]
+
[[Category: Oxygen binding/activation]]
-
[[Category: rieske center]]
+
[[Category: Rieske center]]
-
[[Category: substrate bound complex]]
+
[[Category: Substrate bound complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:01:16 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:27:02 2008''
+

Revision as of 14:01, 3 May 2008

Image:1z01.gif

Template:STRUCTURE 1z01

2-Oxoquinoline 8-Monooxygenase Component: Active site Modulation by Rieske-[2fe-2S] Center Oxidation/Reduction


Overview

2-Oxoquinoline 8-monooxygenase is a Rieske non-heme iron oxygenase that catalyzes the NADH-dependent oxidation of the N-heterocyclic aromatic compound 2-oxoquinoline to 8-hydroxy-2-oxoquinoline in the soil bacterium Pseudomonas putida 86. The crystal structure of the oxygenase component of 2-oxoquinoline 8-monooxygenase shows a ring-shaped, C3-symmetric arrangement in which the mononuclear Fe(II) ion active site of one monomer is at a distance of 13 A from the Rieske-[2Fe-2S] center of a second monomer. Structural analyses of oxidized, reduced, and substrate bound states reveal the molecular bases for a new function of Fe-S clusters. Reduction of the Rieske center modulates the mononuclear Fe through a chain of conformational changes across the subunit interface, resulting in the displacement of Fe and its histidine ligand away from the substrate binding site. This creates an additional coordination site at the mononuclear Fe(II) ion and can open a pathway for dioxygen to bind in the substrate-containing active site.

About this Structure

1Z01 is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

2-Oxoquinoline 8-monooxygenase oxygenase component: active site modulation by Rieske-[2Fe-2S] center oxidation/reduction., Martins BM, Svetlitchnaia T, Dobbek H, Structure. 2005 May;13(5):817-24. PMID:15893671 Page seeded by OCA on Sat May 3 17:01:16 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z01"
Personal tools