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1z0r
From Proteopedia
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[[Image:1z0r.gif|left|200px]] | [[Image:1z0r.gif|left|200px]] | ||
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'''Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB''' | '''Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1Z0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. This structure supersedes the now removed PDB entry | + | 1Z0R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ekt 1ekt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z0R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mueller, G A.]] | [[Category: Mueller, G A.]] | ||
[[Category: Murzin, A G.]] | [[Category: Murzin, A G.]] | ||
| - | [[Category: | + | [[Category: N-terminal dna-binding domain]] |
| - | [[Category: | + | [[Category: Scop database]] |
| - | [[Category: | + | [[Category: Transition state regulator]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:02:47 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:02, 3 May 2008
Solution Structure of the N-terminal DNA Recognition Domain of the Bacillus subtilis Transcription-State Regulator AbrB
Overview
New relationships found in the process of updating the structural classification of proteins (SCOP) database resulted in the revision of the structure of the N-terminal, DNA-binding domain of the transition state regulator AbrB. The dimeric AbrB domain shares a common fold with the addiction antidote MazE and the subunit of uncharacterized protein MraZ implicated in cell division and cell envelope formation. It has a detectable sequence similarity to both MazE and MraZ thus providing an evolutionary link between the two proteins. The putative DNA-binding site of AbrB is found on the same face as the DNA-binding site of MazE and appears similar, both in structure and sequence, to the exposed conserved region of MraZ. This strongly suggests that MraZ also binds DNA and allows for a consensus model of DNA recognition by the members of this novel protein superfamily.
About this Structure
1Z0R is a Single protein structure of sequence from Bacillus subtilis. This structure supersedes the now removed PDB entry 1ekt. Full crystallographic information is available from OCA.
Reference
Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins., Bobay BG, Andreeva A, Mueller GA, Cavanagh J, Murzin AG, FEBS Lett. 2005 Oct 24;579(25):5669-74. Epub 2005 Oct 4. PMID:16223496 Page seeded by OCA on Sat May 3 17:02:47 2008
