1z11

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[[Image:1z11.gif|left|200px]]
[[Image:1z11.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1z11 |SIZE=350|CAPTION= <scene name='initialview01'>1z11</scene>, resolution 2.05&Aring;
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The line below this paragraph, containing "STRUCTURE_1z11", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=8MO:METHOXSALEN'>8MO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CYP2A6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1z11| PDB=1z11 | SCENE= }}
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|RELATEDENTRY=[[1pq2|1PQ2]], [[1r9o|1R9O]], [[1tqn|1TQN]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z11 OCA], [http://www.ebi.ac.uk/pdbsum/1z11 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z11 RCSB]</span>
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}}
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'''Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound'''
'''Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound'''
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[[Category: Stout, C D.]]
[[Category: Stout, C D.]]
[[Category: Yano, J K.]]
[[Category: Yano, J K.]]
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[[Category: coumarin 7-hydroxylase]]
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[[Category: Coumarin 7-hydroxylase]]
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[[Category: cyp2a6]]
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[[Category: Cyp2a6]]
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[[Category: drug metabolizing enzyme]]
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[[Category: Drug metabolizing enzyme]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: methoxsalen]]
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[[Category: Methoxsalen]]
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[[Category: monooxygenase]]
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[[Category: Monooxygenase]]
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[[Category: nicotine oxidase]]
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[[Category: Nicotine oxidase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: p450]]
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[[Category: P450]]
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[[Category: p450 2a6]]
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[[Category: P450 2a6]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:03:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:27:31 2008''
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Revision as of 14:03, 3 May 2008

Image:1z11.gif

Template:STRUCTURE 1z11

Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound


Overview

Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one hydrogen bond donor, Asn297, that orients coumarin for regioselective oxidation. The inhibitor methoxsalen effectively fills the active site cavity without substantially perturbing the structure. The structure should aid the design of inhibitors to reduce smoking and tobacco-related cancers.

About this Structure

1Z11 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen., Yano JK, Hsu MH, Griffin KJ, Stout CD, Johnson EF, Nat Struct Mol Biol. 2005 Sep;12(9):822-3. Epub 2005 Aug 7. PMID:16086027 Page seeded by OCA on Sat May 3 17:03:21 2008

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OCA

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