1z21
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1z21.gif|left|200px]] | [[Image:1z21.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1z21", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1z21| PDB=1z21 | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''Crystal structure of the core domain of Yersinia pestis virulence factor YopR''' | '''Crystal structure of the core domain of Yersinia pestis virulence factor YopR''' | ||
| Line 30: | Line 27: | ||
[[Category: Tropea, J E.]] | [[Category: Tropea, J E.]] | ||
[[Category: Waugh, D S.]] | [[Category: Waugh, D S.]] | ||
| - | [[Category: | + | [[Category: Plague]] |
| - | [[Category: | + | [[Category: Type iii secretion]] |
| - | [[Category: | + | [[Category: Yersinia pesti]] |
| - | [[Category: | + | [[Category: Yop]] |
| - | [[Category: | + | [[Category: Yopr]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:05:27 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:05, 3 May 2008
Crystal structure of the core domain of Yersinia pestis virulence factor YopR
Overview
Yersinia pestis, the causative agent of the plague, employs a type III secretion system (T3SS) to secrete and translocate virulence factors into to the cytoplasm of mammalian host cells. One of the secreted virulence factors is YopR. Little is known about the function of YopR other than that it is secreted into the extracellular milieu during the early stages of infection and that it contributes to virulence. Hoping to gain some insight into the function of YopR, we determined the crystal structure of its protease-resistant core domain, which consists of residues 38-149 out of 165 amino acids. The core domain is composed of five alpha-helices that display unexpected structural similarity with one domain of YopN, a central regulator of type III secretion in Y. pestis. This finding raises the possibility that YopR may play a role in the regulation of type III secretion.
About this Structure
1Z21 is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.
Reference
Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR., Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS, Protein Sci. 2005 Jun;14(6):1679-83. PMID:15930010 Page seeded by OCA on Sat May 3 17:05:27 2008
