1z3i
From Proteopedia
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'''Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54''' | '''Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54''' | ||
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[[Category: Pavletich, N P.]] | [[Category: Pavletich, N P.]] | ||
[[Category: Thoma, N H.]] | [[Category: Thoma, N H.]] | ||
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Revision as of 14:08, 3 May 2008
Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54
Overview
SWI2/SNF2 chromatin-remodeling proteins mediate the mobilization of nucleosomes and other DNA-associated proteins. SWI2/SNF2 proteins contain sequence motifs characteristic of SF2 helicases but do not have helicase activity. Instead, they couple ATP hydrolysis with the generation of superhelical torsion in DNA. The structure of the nucleosome-remodeling domain of zebrafish Rad54, a protein involved in Rad51-mediated homologous recombination, reveals that the core of the SWI2/SNF2 enzymes consist of two alpha/beta-lobes similar to SF2 helicases. The Rad54 helicase lobes contain insertions that form two helical domains, one within each lobe. These insertions contain SWI2/SNF2-specific sequence motifs likely to be central to SWI2/SNF2 function. A broad cleft formed by the two lobes and flanked by the helical insertions contains residues conserved in SWI2/SNF2 proteins and motifs implicated in DNA-binding by SF2 helicases. The Rad54 structure suggests that SWI2/SNF2 proteins use a mechanism analogous to helicases to translocate on dsDNA.
About this Structure
1Z3I is a Single protein structure of sequence from Danio rerio. Full crystallographic information is available from OCA.
Reference
Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54., Thoma NH, Czyzewski BK, Alexeev AA, Mazin AV, Kowalczykowski SC, Pavletich NP, Nat Struct Mol Biol. 2005 Apr;12(4):350-6. Epub 2005 Apr 3. PMID:15806108 Page seeded by OCA on Sat May 3 17:08:24 2008
