1z4n

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[[Image:1z4n.gif|left|200px]]
[[Image:1z4n.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1z4n |SIZE=350|CAPTION= <scene name='initialview01'>1z4n</scene>, resolution 1.97&Aring;
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The line below this paragraph, containing "STRUCTURE_1z4n", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GL1:1-O-PHOSPHONO-BETA-L-ALLOPYRANOSE'>GL1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= pgmB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1358 Lactococcus lactis])
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-->
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|DOMAIN=
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{{STRUCTURE_1z4n| PDB=1z4n | SCENE= }}
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|RELATEDENTRY=[[1z4o|1Z4O]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z4n OCA], [http://www.ebi.ac.uk/pdbsum/1z4n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z4n RCSB]</span>
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}}
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'''Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride'''
'''Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride'''
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[[Category: Tremblay, L W.]]
[[Category: Tremblay, L W.]]
[[Category: Zhang, G.]]
[[Category: Zhang, G.]]
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[[Category: beta-phosphoglucomutase]]
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[[Category: Beta-phosphoglucomutase]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:10:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:02 2008''
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Revision as of 14:10, 3 May 2008

Image:1z4n.gif

Template:STRUCTURE 1z4n

Structure of beta-phosphoglucomutase with inhibitor bound alpha-galactose 1-phosphate cocrystallized with Fluoride


Overview

This communication reports the X-ray crystal structure of the alpha-d-galactose-1-phosphate complex with that of Lactococcus lactis beta-phosphoglucomutase (beta-PGM) crystallized in the presence of Mg2+ cofactor and the enzyme-to-phosphorus ratio determined by protein and phosphate analyses of the crystalline complex. The 1:1 ratio determined for this complex was compared to the 1:2 ratio determined for the crystals of beta-PGM grown in the presence of substrate and Mg2+ cofactor. This result verifies the published structure assignment of this latter complex as the phosphorane adduct formed by covalent bonding between the active site Asp8 carboxylate to the C(1)phosphorus of the beta-glucose 1,6-bisphosphate ligand and rules out the proposal of a beta-PGM-glucose-6-phosphate-1-MgF3- complex.

About this Structure

1Z4N is a Single protein structure of sequence from Lactococcus lactis. Full crystallographic information is available from OCA.

Reference

Chemical confirmation of a pentavalent phosphorane in complex with beta-phosphoglucomutase., Tremblay LW, Zhang G, Dai J, Dunaway-Mariano D, Allen KN, J Am Chem Soc. 2005 Apr 20;127(15):5298-9. PMID:15826149 Page seeded by OCA on Sat May 3 17:10:21 2008

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