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1z56

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[[Image:1z56.gif|left|200px]]
[[Image:1z56.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1z56 |SIZE=350|CAPTION= <scene name='initialview01'>1z56</scene>, resolution 3.92&Aring;
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The line below this paragraph, containing "STRUCTURE_1z56", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= LIF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), DNL4, LIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1z56| PDB=1z56 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z56 OCA], [http://www.ebi.ac.uk/pdbsum/1z56 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z56 RCSB]</span>
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}}
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'''Co-Crystal Structure of Lif1p-Lig4p'''
'''Co-Crystal Structure of Lif1p-Lig4p'''
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==Reference==
==Reference==
Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode., Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL, DNA Repair (Amst). 2006 Mar 7;5(3):362-8. Epub 2006 Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16388993 16388993]
Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode., Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL, DNA Repair (Amst). 2006 Mar 7;5(3):362-8. Epub 2006 Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16388993 16388993]
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[[Category: DNA ligase (ATP)]]
 
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Pellegrini, L.]]
[[Category: Pellegrini, L.]]
[[Category: Sibanda, B L.]]
[[Category: Sibanda, B L.]]
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[[Category: brct]]
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[[Category: Brct]]
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[[Category: coiled-coil]]
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[[Category: Coiled-coil]]
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[[Category: dna ligase]]
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[[Category: Dna ligase]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: nhej]]
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[[Category: Nhej]]
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[[Category: xrcc4]]
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[[Category: Xrcc4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:29:18 2008''
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Revision as of 14:11, 3 May 2008

Image:1z56.gif

Template:STRUCTURE 1z56

Co-Crystal Structure of Lif1p-Lig4p


Overview

DNA ligase IV catalyses the final ligation step in the non-homologous end-joining (NHEJ) DNA repair pathway and requires interaction of the ligase with the Xrcc4 'genome-guardian', an essential NHEJ factor. Here we report the 3.9 A crystal structure of the Saccharomyces cerevisiae Xrcc4 ortholog ligase interacting factor 1 (Lif1p) complexed with the C-terminal BRCT domains of DNA ligase IV (Lig4p). The structure reveals a novel mode of protein recognition by a tandem BRCT repeat, and in addition provides a molecular basis for a human LIG4 syndrome clinical condition.

About this Structure

1Z56 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode., Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL, DNA Repair (Amst). 2006 Mar 7;5(3):362-8. Epub 2006 Jan 18. PMID:16388993 Page seeded by OCA on Sat May 3 17:11:19 2008

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