1z64
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1z64.gif|left|200px]] | [[Image:1z64.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1z64", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1z64| PDB=1z64 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''NMR Solution Structure of Pleurocidin in DPC Micelles''' | '''NMR Solution Structure of Pleurocidin in DPC Micelles''' | ||
| Line 30: | Line 27: | ||
[[Category: Mattatall, N R.]] | [[Category: Mattatall, N R.]] | ||
[[Category: Syvitski, R T.]] | [[Category: Syvitski, R T.]] | ||
| - | [[Category: | + | [[Category: Helix]] |
| - | [[Category: | + | [[Category: Micelle]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:13:10 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:13, 3 May 2008
NMR Solution Structure of Pleurocidin in DPC Micelles
Overview
Pleurocidin is an antimicrobial peptide that was isolated from the mucus membranes of winter flounder (Pseudopleuronectes americanus) and contributes to the initial stages of defense against bacterial infection. From NMR structural studies with the uniformly (15)N-labeled peptide, a structure of pleurocidin was determined to be in a random coil conformation in aqueous solution whereas it assumes an alpha-helical structure in TFE and in dodecylphosphocholine (DPC) micelles. From (15)N relaxation studies, the helix is a rigid structure in the membrane-mimicking environment. Strong NOESY cross-peaks from the pleurocidin to the aliphatic chain on DPC confirm that pleurocidin is contained within the DPC micelle and not associated with the surface of the micelle. From diffusion studies it was determined that each micelle contains at least two pleurocidin molecules.
About this Structure
1Z64 is a Single protein structure of sequence from Pseudopleuronectes americanus. Full crystallographic information is available from OCA.
Reference
Structural characterization of the antimicrobial peptide pleurocidin from winter flounder., Syvitski RT, Burton I, Mattatall NR, Douglas SE, Jakeman DL, Biochemistry. 2005 May 17;44(19):7282-93. PMID:15882067 Page seeded by OCA on Sat May 3 17:13:10 2008
