1z6t

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[[Image:1z6t.gif|left|200px]]
[[Image:1z6t.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1z6t", creates the "Structure Box" on the page.
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{{STRUCTURE_1z6t| PDB=1z6t | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6t OCA], [http://www.ebi.ac.uk/pdbsum/1z6t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z6t RCSB]</span>
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'''Structure of the apoptotic protease-activating factor 1 bound to ADP'''
'''Structure of the apoptotic protease-activating factor 1 bound to ADP'''
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[[Category: Schwarzenbacher, R.]]
[[Category: Schwarzenbacher, R.]]
[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
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[[Category: adp]]
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[[Category: Adp]]
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[[Category: apaf-1]]
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[[Category: Apaf-1]]
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[[Category: card]]
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[[Category: Card]]
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[[Category: caspase activation]]
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[[Category: Caspase activation]]
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[[Category: nucleotide binding]]
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[[Category: Nucleotide binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:14:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:30:14 2008''
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Revision as of 14:14, 3 May 2008

Image:1z6t.gif

Template:STRUCTURE 1z6t

Structure of the apoptotic protease-activating factor 1 bound to ADP


Overview

Apoptosis is executed by caspases, which undergo proteolytic activation in response to cell death stimuli. The apoptotic protease-activating factor 1 (Apaf-1) controls caspase activation downstream of mitochondria. During apoptosis, Apaf-1 binds to cytochrome c and in the presence of ATP/dATP forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9 (ref. 2). The mechanisms underlying Apaf-1 function are largely unknown. Here we report the 2.2-A crystal structure of an ADP-bound, WD40-deleted Apaf-1, which reveals the molecular mechanism by which Apaf-1 exists in an inactive state before ATP binding. The amino-terminal caspase recruitment domain packs against a three-layered alpha/beta fold, a short helical motif and a winged-helix domain, resulting in the burial of the caspase-9-binding interface. The deeply buried ADP molecule serves as an organizing centre to strengthen interactions between these four adjoining domains, thus locking Apaf-1 in an inactive conformation. Apaf-1 binds to and hydrolyses ATP/dATP and their analogues. The binding and hydrolysis of nucleotides seem to drive conformational changes that are essential for the formation of the apoptosome and the activation of caspase-9.

About this Structure

1Z6T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the apoptotic protease-activating factor 1 bound to ADP., Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y, Nature. 2005 Apr 14;434(7035):926-33. PMID:15829969 Page seeded by OCA on Sat May 3 17:14:53 2008

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