1z77

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[[Image:1z77.gif|left|200px]]
[[Image:1z77.gif|left|200px]]
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{{Structure
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1309 AcrR], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam00440 TetR_N]</span>
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{{STRUCTURE_1z77| PDB=1z77 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z77 OCA], [http://www.ebi.ac.uk/pdbsum/1z77 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z77 RCSB]</span>
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'''Crystal structure of transcriptional regulator protein from Thermotoga maritima.'''
'''Crystal structure of transcriptional regulator protein from Thermotoga maritima.'''
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[[Category: Minor, W.]]
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[[Category: Zimmerman, M D.]]
[[Category: Zimmerman, M D.]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: tetr family]]
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[[Category: Tetr family]]
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[[Category: transcriptional regulator]]
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[[Category: Transcriptional regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:15:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:30:35 2008''
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Revision as of 14:15, 3 May 2008

Image:1z77.gif

Template:STRUCTURE 1z77

Crystal structure of transcriptional regulator protein from Thermotoga maritima.


Overview

The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained.

About this Structure

1Z77 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment., Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W, J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774 Page seeded by OCA on Sat May 3 17:15:52 2008

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