1z7z
From Proteopedia
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'''Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi''' | '''Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi''' | ||
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[[Category: Wimmer, E.]] | [[Category: Wimmer, E.]] | ||
[[Category: Xiao, C.]] | [[Category: Xiao, C.]] | ||
| - | [[Category: | + | [[Category: Cryo-electron microscopy,virus-receptor complex]] |
| - | [[Category: | + | [[Category: Icam-1,kilifi,cd54,human coxsackievirus a21]] |
| - | [[Category: | + | [[Category: Icosahedral virus]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:17:28 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:17, 3 May 2008
Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi
Overview
CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1.
About this Structure
1Z7Z is a Protein complex structure of sequences from Homo sapiens and Human coxsackievirus a21. Full crystallographic information is available from OCA.
Reference
The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:16004874 Page seeded by OCA on Sat May 3 17:17:28 2008
Categories: Homo sapiens | Human coxsackievirus a21 | Protein complex | Bator-Kelly, C M. | Chipman, P R. | Craig, A. | Kuhn, R J. | Rieder, E. | Rossmann, M G. | Wimmer, E. | Xiao, C. | Cryo-electron microscopy,virus-receptor complex | Icam-1,kilifi,cd54,human coxsackievirus a21 | Icosahedral virus
