1z8l

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[[Image:1z8l.gif|left|200px]]
[[Image:1z8l.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1z8l |SIZE=350|CAPTION= <scene name='initialview01'>1z8l</scene>, resolution 3.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1z8l", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate_carboxypeptidase_II Glutamate carboxypeptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.21 3.4.17.21] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FOLH1, FOLH, NAALAD1, PSM, PSMA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1z8l| PDB=1z8l | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z8l OCA], [http://www.ebi.ac.uk/pdbsum/1z8l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z8l RCSB]</span>
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}}
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'''Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase'''
'''Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase'''
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[[Category: Davis, M I.]]
[[Category: Davis, M I.]]
[[Category: Thomas, L M.]]
[[Category: Thomas, L M.]]
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[[Category: dimeric protein with three domains of type a+b]]
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[[Category: Dimeric protein with three domains of type a+b]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:18:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:32:04 2008''
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Revision as of 14:18, 3 May 2008

Image:1z8l.gif

Template:STRUCTURE 1z8l

Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase


Overview

Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer cells and nonprostatic solid tumor neovasculature and is a target for anticancer imaging and therapeutic agents. PSMA acts as a glutamate carboxypeptidase (GCPII) on small molecule substrates, including folate, the anticancer drug methotrexate, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate. Here we present the 3.5-A crystal structure of the PSMA ectodomain, which reveals a homodimer with structural similarity to transferrin receptor, a receptor for iron-loaded transferrin that lacks protease activity. Unlike transferrin receptor, the protease domain of PSMA contains a binuclear zinc site, catalytic residues, and a proposed substrate-binding arginine patch. Elucidation of the PSMA structure combined with docking studies and a proposed catalytic mechanism provides insight into the recognition of inhibitors and the natural substrate N-acetyl-l-aspartyl-l-glutamate. The PSMA structure will facilitate development of chemotherapeutics, cancer-imaging agents, and agents for treatment of neurological disorders.

About this Structure

1Z8L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase., Davis MI, Bennett MJ, Thomas LM, Bjorkman PJ, Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5981-6. Epub 2005 Apr 18. PMID:15837926 Page seeded by OCA on Sat May 3 17:18:54 2008

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OCA

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