1z9o

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[[Image:1z9o.gif|left|200px]]
[[Image:1z9o.gif|left|200px]]
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{{Structure
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|PDB= 1z9o |SIZE=350|CAPTION= <scene name='initialview01'>1z9o</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1z9o", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= Vapa, Vap33 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_1z9o| PDB=1z9o | SCENE= }}
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|RELATEDENTRY=[[1z9l|1Z9L]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z9o OCA], [http://www.ebi.ac.uk/pdbsum/1z9o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z9o RCSB]</span>
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}}
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'''1.9 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain in Complex with the Rat ORP1 FFAT Motif'''
'''1.9 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain in Complex with the Rat ORP1 FFAT Motif'''
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[[Category: Reilein, A R.]]
[[Category: Reilein, A R.]]
[[Category: Walter, P.]]
[[Category: Walter, P.]]
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[[Category: endoplasmic reticulum]]
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[[Category: Endoplasmic reticulum]]
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[[Category: er]]
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[[Category: Er]]
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[[Category: erg30]]
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[[Category: Erg30]]
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[[Category: ffat motif]]
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[[Category: Ffat motif]]
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[[Category: immunoglobulin-like beta sheet]]
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[[Category: Immunoglobulin-like beta sheet]]
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[[Category: msp homology domain]]
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[[Category: Msp homology domain]]
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[[Category: orp]]
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[[Category: Orp]]
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[[Category: osbp]]
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[[Category: Osbp]]
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[[Category: oxysterol binding protein]]
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[[Category: Oxysterol binding protein]]
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[[Category: scs2]]
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[[Category: Scs2]]
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[[Category: targeting]]
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[[Category: Targeting]]
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[[Category: vap-33]]
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[[Category: Vap-33]]
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[[Category: vap-33a]]
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[[Category: Vap-33a]]
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[[Category: vap-a]]
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[[Category: Vap-a]]
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[[Category: vap-b]]
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[[Category: Vap-b]]
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[[Category: vap-c]]
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[[Category: Vap-c]]
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[[Category: vapa]]
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[[Category: Vapa]]
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[[Category: vapb]]
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[[Category: Vapb]]
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[[Category: vapc]]
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[[Category: Vapc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:21:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:32:46 2008''
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Revision as of 14:21, 3 May 2008

Image:1z9o.gif

Template:STRUCTURE 1z9o

1.9 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain in Complex with the Rat ORP1 FFAT Motif


Overview

The FFAT motif is a targeting signal responsible for localizing a number of proteins to the cytosolic surface of the endoplasmic reticulum (ER) and to the nuclear membrane. FFAT motifs bind to members of the highly conserved VAP protein family, which are tethered to the cytoplasmic face of the ER by a C-terminal transmembrane domain. We have solved crystal structures of the rat VAP-A MSP homology domain alone and in complex with an FFAT motif. The co-crystal structure was used to design a VAP mutant that disrupts rat and yeast VAP-FFAT interactions in vitro. The FFAT binding-defective mutant also blocked function of the VAP homolog Scs2p in yeast. Finally, overexpression of the FFAT binding-defective VAP in COS7 cells dramatically altered ER morphology. Our data establish the structural basis of FFAT-mediated ER targeting and suggest that FFAT-targeted proteins play an important role in determining ER morphology.

About this Structure

1Z9O is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis of FFAT motif-mediated ER targeting., Kaiser SE, Brickner JH, Reilein AR, Fenn TD, Walter P, Brunger AT, Structure. 2005 Jul;13(7):1035-45. PMID:16004875 Page seeded by OCA on Sat May 3 17:21:23 2008

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