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1zaf

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[[Image:1zaf.gif|left|200px]]
[[Image:1zaf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zaf |SIZE=350|CAPTION= <scene name='initialview01'>1zaf</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1zaf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=789:3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE'>789</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ESR2, ESTRB, NR3A2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1zaf| PDB=1zaf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zaf OCA], [http://www.ebi.ac.uk/pdbsum/1zaf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zaf RCSB]</span>
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}}
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'''Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one'''
'''Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one'''
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[[Category: Unwalla, R J.]]
[[Category: Unwalla, R J.]]
[[Category: Xu, Z B.]]
[[Category: Xu, Z B.]]
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[[Category: agonist]]
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[[Category: Agonist]]
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[[Category: er]]
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[[Category: Er]]
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[[Category: er-beta]]
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[[Category: Er-beta]]
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[[Category: estrogen]]
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[[Category: Estrogen]]
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[[Category: estrogen receptor]]
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[[Category: Estrogen receptor]]
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[[Category: estrogen receptor beta]]
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[[Category: Estrogen receptor beta]]
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[[Category: nuclear receptor]]
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[[Category: Nuclear receptor]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:23:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:33:05 2008''
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Revision as of 14:23, 3 May 2008

Image:1zaf.gif

Template:STRUCTURE 1zaf

Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one


Overview

The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.

About this Structure

1ZAF is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones., McDevitt RE, Malamas MS, Manas ES, Unwalla RJ, Xu ZB, Miller CP, Harris HA, Bioorg Med Chem Lett. 2005 Jun 15;15(12):3137-42. PMID:15876535 Page seeded by OCA on Sat May 3 17:23:12 2008

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OCA

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