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1zap
From Proteopedia
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[[Image:1zap.gif|left|200px]] | [[Image:1zap.gif|left|200px]] | ||
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'''SECRETED ASPARTIC PROTEASE FROM C. ALBICANS''' | '''SECRETED ASPARTIC PROTEASE FROM C. ALBICANS''' | ||
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[[Category: Abad-Zapatero, C.]] | [[Category: Abad-Zapatero, C.]] | ||
[[Category: Muchmore, S W.]] | [[Category: Muchmore, S W.]] | ||
| - | [[Category: | + | [[Category: Aspartic protease]] |
| - | [[Category: | + | [[Category: Candida albican]] |
| - | [[Category: | + | [[Category: Secreted]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:23:51 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:23, 3 May 2008
SECRETED ASPARTIC PROTEASE FROM C. ALBICANS
Overview
The three-dimensional structure of a secreted aspartic protease from Candida albicans complexed with a potent inhibitor reveals variations on the classical aspartic protease theme that dramatically alter the specificity of this class of enzymes. The structure presents: (1) an 8-residue insertion near the first disulfide (Cys 45-Cys 50, pepsin numbering) that results in a broad flap extending toward the active site; (2) a 7-residue deletion replacing helix hN2 (Ser 110-Tyr 114), which enlarges the S3 pocket; (3) a short polar connection between the two rigid body domains that alters their relative orientation and provides certain specificity; and (4) an ordered 11-residue addition at the carboxy terminus. The inhibitor binds in an extended conformation and presents a branched structure at the P3 position. The implications of these findings for the design of potent antifungal agents are discussed.
About this Structure
1ZAP is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.
Reference
Structure of a secreted aspartic protease from C. albicans complexed with a potent inhibitor: implications for the design of antifungal agents., Abad-Zapatero C, Goldman R, Muchmore SW, Hutchins C, Stewart K, Navaza J, Payne CD, Ray TL, Protein Sci. 1996 Apr;5(4):640-52. PMID:8845753 Page seeded by OCA on Sat May 3 17:23:51 2008
