1zbe
From Proteopedia
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'''Foot-and Mouth Disease Virus Serotype A1061''' | '''Foot-and Mouth Disease Virus Serotype A1061''' | ||
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[[Category: Newman, J W.]] | [[Category: Newman, J W.]] | ||
[[Category: Stuart, D I.]] | [[Category: Stuart, D I.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:25:04 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:25, 3 May 2008
Foot-and Mouth Disease Virus Serotype A1061
Overview
Foot-and-mouth disease viruses (FMDVs) target epithelial cells via integrin receptors, but can acquire the capacity to bind cell-surface heparan sulphate (or alternative receptors) on passage in cell culture. Vaccine viruses must be propagated in cell culture and, hence, some rationale for the selection of variants in this process is important. Crystal structures are available for type O, A and C viruses and also for a complex of type O strain O(1)BFS with heparin. The structure of FMDV A10(61) (a cell culture-adapted strain) complexed with heparin has now been determined. This virus has an RGSD motif in place of the otherwise conserved RGD integrin-binding motif and the potential to bind heparan sulphate (suggested by sequence analyses). FMDV A10(61) was closely similar in structure to other serotypes, deviating most in antigenic sites. The VP1 GH loop comprising the integrin-binding motif was disordered. Heparin bound at a similar site and in a similar conformation to that seen in the analogous complex with O(1)BFS, although the binding had a lower affinity and was more ionic.
About this Structure
1ZBE is a Protein complex structure of sequences from Foot-and-mouth disease virus. Full crystallographic information is available from OCA.
Reference
Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation., Fry EE, Newman JW, Curry S, Najjam S, Jackson T, Blakemore W, Lea SM, Miller L, Burman A, King AM, Stuart DI, J Gen Virol. 2005 Jul;86(Pt 7):1909-20. PMID:15958669 Page seeded by OCA on Sat May 3 17:25:04 2008
