1ze3

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[[Image:1ze3.gif|left|200px]]
[[Image:1ze3.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ze3", creates the "Structure Box" on the page.
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|GENE= fimC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), fimH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli]), fimD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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{{STRUCTURE_1ze3| PDB=1ze3 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ze3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ze3 OCA], [http://www.ebi.ac.uk/pdbsum/1ze3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ze3 RCSB]</span>
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'''Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH'''
'''Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH'''
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[[Category: Vetsch, M.]]
[[Category: Vetsch, M.]]
[[Category: Wuthrich, K.]]
[[Category: Wuthrich, K.]]
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[[Category: soluble domain]]
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[[Category: Soluble domain]]
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[[Category: ternary complex with chaperone and pilus subunit]]
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[[Category: Ternary complex with chaperone and pilus subunit]]
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[[Category: usher]]
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[[Category: Usher]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:30:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:34:42 2008''
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Revision as of 14:30, 3 May 2008

Image:1ze3.gif

Template:STRUCTURE 1ze3

Crystal Structure of the Ternary Complex of FIMD (N-Terminal Domain) with FIMC and the Pilin Domain of FIMH


Overview

Adhesive type 1 pili from uropathogenic Escherichia coli are filamentous protein complexes that are attached to the assembly platform FimD in the outer membrane. During pilus assembly, FimD binds complexes between the chaperone FimC and type 1 pilus subunits in the periplasm and mediates subunit translocation to the cell surface. Here we report nuclear magnetic resonance and X-ray protein structures of the N-terminal substrate recognition domain of FimD (FimD(N)) before and after binding of a chaperone-subunit complex. FimD(N) consists of a flexible N-terminal segment of 24 residues, a structured core with a novel fold, and a C-terminal hinge segment. In the ternary complex, residues 1-24 of FimD(N) specifically interact with both FimC and the subunit, acting as a sensor for loaded FimC molecules. Together with in vivo complementation studies, we show how this mechanism enables recognition and discrimination of different chaperone-subunit complexes by bacterial pilus assembly platforms.

About this Structure

1ZE3 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD., Nishiyama M, Horst R, Eidam O, Herrmann T, Ignatov O, Vetsch M, Bettendorff P, Jelesarov I, Grutter MG, Wuthrich K, Glockshuber R, Capitani G, EMBO J. 2005 Jun 15;24(12):2075-86. Epub 2005 May 26. PMID:15920478 Page seeded by OCA on Sat May 3 17:30:53 2008

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