1zea

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[[Image:1zea.gif|left|200px]]
[[Image:1zea.gif|left|200px]]
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{{Structure
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|PDB= 1zea |SIZE=350|CAPTION= <scene name='initialview01'>1zea</scene>, resolution 1.78&Aring;
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The line below this paragraph, containing "STRUCTURE_1zea", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=DAS:D-ASPARTIC+ACID'>DAS</scene>, <scene name='pdbligand=DGN:D-GLUTAMINE'>DGN</scene>, <scene name='pdbligand=DHI:D-HISTIDINE'>DHI</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=DTY:D-TYROSINE'>DTY</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>
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{{STRUCTURE_1zea| PDB=1zea | SCENE= }}
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|RELATEDENTRY=[[1tet|1TET]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zea OCA], [http://www.ebi.ac.uk/pdbsum/1zea PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zea RCSB]</span>
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'''Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide'''
'''Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide'''
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==About this Structure==
==About this Structure==
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1ZEA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZEA OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZEA OCA].
==Reference==
==Reference==
Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition., Scheerer P, Kramer A, Otte L, Seifert M, Wessner H, Scholz C, Krauss N, Schneider-Mergener J, Hohne W, J Mol Recognit. 2007 Jul-Aug;20(4):263-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17712773 17712773]
Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition., Scheerer P, Kramer A, Otte L, Seifert M, Wessner H, Scholz C, Krauss N, Schneider-Mergener J, Hohne W, J Mol Recognit. 2007 Jul-Aug;20(4):263-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17712773 17712773]
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[[Category: Mus musculus]]
 
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[[Category: Protein complex]]
 
[[Category: Hoehne, W.]]
[[Category: Hoehne, W.]]
[[Category: Kramer, A.]]
[[Category: Kramer, A.]]
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[[Category: Seifert, M.]]
[[Category: Seifert, M.]]
[[Category: Wessner, H.]]
[[Category: Wessner, H.]]
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[[Category: anti-cholera toxin]]
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[[Category: Anti-cholera toxin]]
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[[Category: antigen recognition]]
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[[Category: Antigen recognition]]
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[[Category: antigen-antibody complex]]
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[[Category: Antigen-antibody complex]]
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[[Category: cross-reactivity]]
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[[Category: Cross-reactivity]]
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[[Category: polyspecificity]]
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[[Category: Polyspecificity]]
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[[Category: substitution matrix]]
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[[Category: Substitution matrix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:31:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:34:50 2008''
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Revision as of 14:31, 3 May 2008

Image:1zea.gif

Template:STRUCTURE 1zea

Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide


Overview

The structure of a complex of the anti-cholera toxin antibody TE33 Fab (fragment antibody) with the D-peptide vpGsqhyds was solved to 1.78 A resolution. The D-peptide was derived from the linear L-peptide epitope VPGSQHIDS by a stepwise transformation. Despite the very similar amino acid sequence-the only difference is a tyrosine residue in position 7-there are marked differences in the individual positions with respect to their contribution to the peptide overall affinity as ascertained by a complete substitutional analysis. This is reflected by the X-ray structure of the TE33 Fab/D-peptide complex where there is an inverted orientation of the D-peptide as compared with the known structure of a corresponding complex containing the epitope L-peptide, with the side chains establishing different contacts within the binding site of TE33. The D- and L-peptide affinities are comparable and the surface areas buried by complex formation are almost the same. Thus the antibody TE33 provides a typical example for polyspecific binding behavior of IgG family antibodies.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition., Scheerer P, Kramer A, Otte L, Seifert M, Wessner H, Scholz C, Krauss N, Schneider-Mergener J, Hohne W, J Mol Recognit. 2007 Jul-Aug;20(4):263-74. PMID:17712773 Page seeded by OCA on Sat May 3 17:31:12 2008

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