1zho

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[[Image:1zho.gif|left|200px]]
[[Image:1zho.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zho |SIZE=350|CAPTION= <scene name='initialview01'>1zho</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1zho", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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|GENE= rplA, rpl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])
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|DOMAIN=
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{{STRUCTURE_1zho| PDB=1zho | SCENE= }}
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|RELATEDENTRY=[[1i2a|1i2a]], [[1u63|1U63]], [[1dwu|1DWU]], [[1mzp|1mzp]], [[1ad2|1ad2]], [[1csj|1CSJ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zho OCA], [http://www.ebi.ac.uk/pdbsum/1zho PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zho RCSB]</span>
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'''The structure of a ribosomal protein L1 in complex with mRNA'''
'''The structure of a ribosomal protein L1 in complex with mRNA'''
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[[Category: Volchkov, S.]]
[[Category: Volchkov, S.]]
[[Category: Zimmermann, R.]]
[[Category: Zimmermann, R.]]
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[[Category: l1]]
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[[Category: L1]]
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[[Category: mrna-protein complex]]
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[[Category: Mrna-protein complex]]
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[[Category: regulation of gene expression]]
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[[Category: Regulation of gene expression]]
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[[Category: ribosomal protein]]
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[[Category: Ribosomal protein]]
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[[Category: ribosome]]
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[[Category: Ribosome]]
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[[Category: rna-protein interaction]]
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[[Category: Rna-protein interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:38:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:36:42 2008''
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Revision as of 14:38, 3 May 2008

Image:1zho.gif

Template:STRUCTURE 1zho

The structure of a ribosomal protein L1 in complex with mRNA


Overview

The RNA-binding ability of ribosomal protein L1 is of profound interest, since L1 has a dual function as a ribosomal structural protein that binds rRNA and as a translational repressor that binds its own mRNA. Here, we report the crystal structure at 2.6 A resolution of ribosomal protein L1 from the bacterium Thermus thermophilus in complex with a 38 nt fragment of L1 mRNA from Methanoccocus vannielii. The conformation of RNA-bound T.thermophilus L1 differs dramatically from that of the isolated protein. Analysis of four copies of the L1-mRNA complex in the crystal has shown that domain II of the protein does not contribute to mRNA-specific binding. A detailed comparison of the protein-RNA interactions in the L1-mRNA and L1-rRNA complexes identified amino acid residues of L1 crucial for recognition of its specific targets on the both RNAs. Incorporation of the structure of bacterial L1 into a model of the Escherichia coli ribosome revealed two additional contact regions for L1 on the 23S rRNA that were not identified in previous ribosome models.

About this Structure

1ZHO is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

New insights into the interaction of ribosomal protein L1 with RNA., Nevskaya N, Tishchenko S, Volchkov S, Kljashtorny V, Nikonova E, Nikonov O, Nikulin A, Kohrer C, Piendl W, Zimmermann R, Stockley P, Garber M, Nikonov S, J Mol Biol. 2006 Jan 27;355(4):747-59. Epub 2005 Nov 17. PMID:16330048 Page seeded by OCA on Sat May 3 17:38:11 2008

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