1zhu
From Proteopedia
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[[Image:1zhu.gif|left|200px]] | [[Image:1zhu.gif|left|200px]] | ||
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'''DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES''' | '''DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZHU OCA]. | |
==Reference== | ==Reference== | ||
Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA., Zhu L, Chou SH, Xu J, Reid BR, Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7583654 7583654] | Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA., Zhu L, Chou SH, Xu J, Reid BR, Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7583654 7583654] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Chou, S H.]] | [[Category: Chou, S H.]] | ||
[[Category: Reid, B R.]] | [[Category: Reid, B R.]] | ||
[[Category: Xu, J.]] | [[Category: Xu, J.]] | ||
[[Category: Zhu, L.]] | [[Category: Zhu, L.]] | ||
| - | [[Category: | + | [[Category: Dna hairpin]] |
| - | [[Category: | + | [[Category: Ga mismatch]] |
| - | [[Category: | + | [[Category: Single residue loop]] |
| - | [[Category: | + | [[Category: Triplet disease]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:38:32 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:38, 3 May 2008
DNA (5'-D(*CP*AP*AP*TP*GP*CP*AP*AP*TP*G)-3'), NMR, 10 STRUCTURES
Overview
In certain contexts the DNA triplet GGA, when juxtaposed on opposite strands of a DNA duplex, shows the unusual property of pairing with itself in an antiparallel orientation to form the (GGA)2 motif. In this motif the central guanines do not pair but intercalate and stack between sheared G.A pairs. Similar studies with GCA triplets reveal that they do not form analogous paired (GCA)2 motifs but instead strongly promote formation of a hairpin, the structure of which is now reported here. The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structure of a single-cytidine hairpin loop formed by the DNA triplet GCA., Zhu L, Chou SH, Xu J, Reid BR, Nat Struct Biol. 1995 Nov;2(11):1012-7. PMID:7583654 Page seeded by OCA on Sat May 3 17:38:32 2008
