2cyx

From Proteopedia

---

Revision as of 19:18, 12 November 2007

proteopedia linkproteopedia link

spinqualitylabelsall models 2cyx, resolution 2.56Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)

Overview

The human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7) is involved in, protein degradation, including a process known as endoplasmic, reticulum-associated degradation (ERAD). The crystal structure of human, UBE2G2/UBC7 was solved at 2.56 angstroms resolution. The UBE2G2 structure, comprises a single domain consisting of an antiparallel beta-sheet with, four strands, five alpha-helices and two 3(10)-helices. Structural, comparison of human UBE2G2 with yeast Ubc7 indicated that the overall, structures are similar except for the long loop region and the C-terminal, helix. Superimposition of UBE2G2 on UbcH7 in a c-Cbl-UbcH7-ZAP70 ternary, complex suggested that the two loop regions of UBE2G2 interact with the, RING domain in a similar way to UbcH7. In addition, the extra loop region, of UBE2G2 may interact with the RING domain or its neighbouring region and, may be involved in the binding specificity and stability.

About this Structure

2CYX is a Single protein structure of sequence from Homo sapiens. Active as Ubiquitin--protein ligase, with EC number 6.3.2.19 Full crystallographic information is available from OCA.

Reference

Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7)., Arai R, Yoshikawa S, Murayama K, Imai Y, Takahashi R, Shirouzu M, Yokoyama S, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):330-4. Epub 2006 Mar 25. PMID:16582478

Page seeded by OCA on Mon Nov 12 21:24:42 2007