1zla

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[[Image:1zla.gif|left|200px]]
[[Image:1zla.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zla |SIZE=350|CAPTION= <scene name='initialview01'>1zla</scene>, resolution 2.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1zla", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Alpha-Satellite DNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Histone H3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis]), Histone H4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis]), Histone H2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28384 other sequences]), Histone H2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 Xenopus laevis])
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-->
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|DOMAIN=
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{{STRUCTURE_1zla| PDB=1zla | SCENE= }}
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|RELATEDENTRY=[[1aoi|1aoi]], [[1f66|1f66]], [[1kx3|1kx3]], [[1kx4|1kx4]], [[1kx5|1kx5]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zla OCA], [http://www.ebi.ac.uk/pdbsum/1zla PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zla RCSB]</span>
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}}
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'''X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core'''
'''X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core'''
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[[Category: Kaye, K M.]]
[[Category: Kaye, K M.]]
[[Category: Luger, K.]]
[[Category: Luger, K.]]
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[[Category: chromatin]]
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[[Category: Chromatin]]
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[[Category: kaposi's sarcoma herpes virus (kshv)]]
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[[Category: Nucleosome core particle]]
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[[Category: latency associated nuclear antigen (lana)]]
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[[Category: Protein/protein interaction]]
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[[Category: nucleosome core particle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:45:48 2008''
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[[Category: protein/protein interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:38:11 2008''
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Revision as of 14:45, 3 May 2008

Image:1zla.gif

Template:STRUCTURE 1zla

X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core


Overview

Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) mediates viral genome attachment to mitotic chromosomes. We find that N-terminal LANA docks onto chromosomes by binding nucleosomes through the folded region of histones H2A-H2B. The same LANA residues were required for both H2A-H2B binding and chromosome association. Further, LANA did not bind Xenopus sperm chromatin, which is deficient in H2A-H2B; chromatin binding was rescued after assembly of nucleosomes containing H2A-H2B. We also describe the 2.9-angstrom crystal structure of a nucleosome complexed with the first 23 LANA amino acids. The LANA peptide forms a hairpin that interacts exclusively with an acidic H2A-H2B region that is implicated in the formation of higher order chromatin structure. Our findings present a paradigm for how nucleosomes may serve as binding platforms for viral and cellular proteins and reveal a previously unknown mechanism for KSHV latency.

About this Structure

1ZLA is a Protein complex structure of sequences from Homo sapiens, Xenopus laevis and Other sequences. Full crystallographic information is available from OCA.

Reference

The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA., Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Joukov V, Walter JC, Luger K, Kaye KM, Science. 2006 Feb 10;311(5762):856-61. PMID:16469929 Page seeded by OCA on Sat May 3 17:45:48 2008

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OCA

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