This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1zmf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1zmf.gif|left|200px]]
[[Image:1zmf.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1zmf |SIZE=350|CAPTION= <scene name='initialview01'>1zmf</scene>, resolution 1.88&Aring;
+
The line below this paragraph, containing "STRUCTURE_1zmf", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1zmf| PDB=1zmf | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zmf OCA], [http://www.ebi.ac.uk/pdbsum/1zmf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zmf RCSB]</span>
+
-
}}
+
'''C domain of human cyclophilin-33(hcyp33)'''
'''C domain of human cyclophilin-33(hcyp33)'''
Line 31: Line 28:
[[Category: Wang, T.]]
[[Category: Wang, T.]]
[[Category: Yun, C H.]]
[[Category: Yun, C H.]]
-
[[Category: human cyclophilin-33]]
+
[[Category: Human cyclophilin-33]]
-
[[Category: ppiase]]
+
[[Category: Ppiase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:48:25 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:38:41 2008''
+

Revision as of 14:48, 3 May 2008

Image:1zmf.gif

Template:STRUCTURE 1zmf

C domain of human cyclophilin-33(hcyp33)


Overview

Cyclophilins (CyPs) are a widespreading protein family in living organisms and possess the activity of peptidyl-prolyl cis-trans isomerase (PPIase), which is inhibited by cyclosporin A (CsA). The human nuclear cyclophilin (hCyP33) is the first protein which was found to contain two RNA binding domains at the amino-terminus and a PPIase domain at the carboxyl-terminus. We isolated the hCyP33 gene from the human hematopoietic stem/progenitor cells and expressed it in Escherichia coli, and determined the crystal structure of the C domain of hCyP33 at 1.88 A resolution. The core structure is a beta-barrel covered by two alpha-helices. Superposition of the structure of the C domain of hCyP33 with the structure of CypA suggests that the C domain contains PPIase active site which binds to CsA. Furthermore, C domain seems to be able to bind with the Gag-encoded capsid (CA) of HIV-1 and may affect the viral replication of HIV-1. A key residue of the active site is changed from Ala-103-CypA to Ser-239-hCyP33, which may affect the PPIase domain/substrates interactions.

About this Structure

1ZMF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase., Wang T, Yun CH, Gu SY, Chang WR, Liang DC, Biochem Biophys Res Commun. 2005 Aug 5;333(3):845-9. PMID:15963461 Page seeded by OCA on Sat May 3 17:48:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zmf"
Personal tools