1zmf

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[[Image:1zmf.gif|left|200px]]
[[Image:1zmf.gif|left|200px]]
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{{Structure
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|PDB= 1zmf |SIZE=350|CAPTION= <scene name='initialview01'>1zmf</scene>, resolution 1.88&Aring;
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The line below this paragraph, containing "STRUCTURE_1zmf", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
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{{STRUCTURE_1zmf| PDB=1zmf | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zmf OCA], [http://www.ebi.ac.uk/pdbsum/1zmf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zmf RCSB]</span>
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'''C domain of human cyclophilin-33(hcyp33)'''
'''C domain of human cyclophilin-33(hcyp33)'''
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[[Category: Wang, T.]]
[[Category: Wang, T.]]
[[Category: Yun, C H.]]
[[Category: Yun, C H.]]
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[[Category: human cyclophilin-33]]
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[[Category: Human cyclophilin-33]]
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[[Category: ppiase]]
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[[Category: Ppiase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:48:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:38:41 2008''
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Revision as of 14:48, 3 May 2008

Image:1zmf.gif

Template:STRUCTURE 1zmf

C domain of human cyclophilin-33(hcyp33)


Overview

Cyclophilins (CyPs) are a widespreading protein family in living organisms and possess the activity of peptidyl-prolyl cis-trans isomerase (PPIase), which is inhibited by cyclosporin A (CsA). The human nuclear cyclophilin (hCyP33) is the first protein which was found to contain two RNA binding domains at the amino-terminus and a PPIase domain at the carboxyl-terminus. We isolated the hCyP33 gene from the human hematopoietic stem/progenitor cells and expressed it in Escherichia coli, and determined the crystal structure of the C domain of hCyP33 at 1.88 A resolution. The core structure is a beta-barrel covered by two alpha-helices. Superposition of the structure of the C domain of hCyP33 with the structure of CypA suggests that the C domain contains PPIase active site which binds to CsA. Furthermore, C domain seems to be able to bind with the Gag-encoded capsid (CA) of HIV-1 and may affect the viral replication of HIV-1. A key residue of the active site is changed from Ala-103-CypA to Ser-239-hCyP33, which may affect the PPIase domain/substrates interactions.

About this Structure

1ZMF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase., Wang T, Yun CH, Gu SY, Chang WR, Liang DC, Biochem Biophys Res Commun. 2005 Aug 5;333(3):845-9. PMID:15963461 Page seeded by OCA on Sat May 3 17:48:25 2008

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