1znn
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1znn.gif|left|200px]] | [[Image:1znn.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1znn", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1znn| PDB=1znn | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Structure of the synthase subunit of PLP synthase''' | '''Structure of the synthase subunit of PLP synthase''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNN OCA]. | |
==Reference== | ==Reference== | ||
A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase., Zhu J, Burgner JW, Harms E, Belitsky BR, Smith JL, J Biol Chem. 2005 Jul 29;280(30):27914-23. Epub 2005 May 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15911615 15911615] | A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase., Zhu J, Burgner JW, Harms E, Belitsky BR, Smith JL, J Biol Chem. 2005 Jul 29;280(30):27914-23. Epub 2005 May 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15911615 15911615] | ||
| - | [[Category: Geobacillus stearothermophilus]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Belitsky, B R.]] | [[Category: Belitsky, B R.]] | ||
[[Category: Burgner, J W.]] | [[Category: Burgner, J W.]] | ||
| Line 30: | Line 25: | ||
[[Category: Smith, J L.]] | [[Category: Smith, J L.]] | ||
[[Category: Zhu, J.]] | [[Category: Zhu, J.]] | ||
| - | [[Category: | + | [[Category: Tim barrel]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:51:02 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:51, 3 May 2008
Structure of the synthase subunit of PLP synthase
Overview
Pyridoxal 5'-phosphate (PLP, vitamin B6), a cofactor in many enzymatic reactions, has two distinct biosynthetic routes, which do not coexist in any organism. Two proteins, known as PdxS and PdxT, together form a PLP synthase in plants, fungi, archaea, and some eubacteria. PLP synthase is a heteromeric glutamine amidotransferase in which PdxT produces ammonia from glutamine and PdxS combines ammonia with five- and three-carbon phosphosugars to form PLP. In the 2.2-A crystal structure, PdxS is a cylindrical dodecamer of subunits having the classic (beta/alpha)8 barrel fold. PdxS subunits form two hexameric rings with the active sites positioned on the inside. The hexamer and dodecamer forms coexist in solution. A novel phosphate-binding site is suggested by bound sulfate. The sulfate and another bound molecule, methyl pentanediol, were used to model the substrate ribulose 5-phosphate, and to propose catalytic roles for residues in the active site. The distribution of conserved surfaces in the PdxS dodecamer was used to predict a docking site for the glutaminase partner, PdxT.
About this Structure
Full crystallographic information is available from OCA.
Reference
A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase., Zhu J, Burgner JW, Harms E, Belitsky BR, Smith JL, J Biol Chem. 2005 Jul 29;280(30):27914-23. Epub 2005 May 23. PMID:15911615 Page seeded by OCA on Sat May 3 17:51:02 2008
