1zno

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1zno.gif|left|200px]]
[[Image:1zno.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1zno |SIZE=350|CAPTION= <scene name='initialview01'>1zno</scene>, resolution 2.&Aring;
+
The line below this paragraph, containing "STRUCTURE_1zno", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= vibrio cholerae ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 Vibrio cholerae])
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK05074 PRK05074]</span>
+
{{STRUCTURE_1zno| PDB=1zno | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zno OCA], [http://www.ebi.ac.uk/pdbsum/1zno PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zno RCSB]</span>
+
-
}}
+
'''Crystal Structure of VC702 from Vibrio Cholerae, Northeast Structural Genomics Consortium Target: VcP1'''
'''Crystal Structure of VC702 from Vibrio Cholerae, Northeast Structural Genomics Consortium Target: VcP1'''
Line 31: Line 28:
[[Category: Ni, S.]]
[[Category: Ni, S.]]
[[Category: Robinson, H.]]
[[Category: Robinson, H.]]
-
[[Category: homodimer]]
+
[[Category: Homodimer]]
-
[[Category: mixed alpha/beta sandwich]]
+
[[Category: Mixed alpha/beta sandwich]]
-
[[Category: nesg]]
+
[[Category: Nesg]]
-
[[Category: northeast structural genomics consortium]]
+
[[Category: Northeast structural genomics consortium]]
-
[[Category: protein structure initiative]]
+
[[Category: Protein structure initiative]]
-
[[Category: psi]]
+
[[Category: Psi]]
-
[[Category: structural genomic]]
+
[[Category: Structural genomic]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:51:08 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:39:15 2008''
+

Revision as of 14:51, 3 May 2008

Template:STRUCTURE 1zno

Crystal Structure of VC702 from Vibrio Cholerae, Northeast Structural Genomics Consortium Target: VcP1


Overview

VC0702, a conserved hypothetical protein of unknown function from Vibrio cholerae, resides in a three-gene operon containing the MbaA gene that encodes for a GGDEF and EAL domain-containing protein which is involved in regulating formation of the extracellular matrix of biofilms in Vibrio cholerae. The VC0702 crystal structure has been determined at 2.0 A and refined to Rwork = 22.8% and Rfree = 26.3%. VC0702 crystallized in an orthorhombic crystal lattice in the C222(1) space group with dimensions of a = 66.61 A, b = 88.118 A, and c = 118.35 A with a homodimer in the asymmetric unit. VC0702, which forms a mixed alpha + beta three-layered alphabetaalpha sandwich, belongs to the Pfam DUF84 and COG1986 families of proteins. Sequence conservation within the DUF84 and COG1986 families was used to identify a conserved patch of surface residues that define a cleft and potential substrate-binding site in VC0702. The three-dimensional structure of VC0702 is similar to that of Mj0226 from Methanococcus janeschii, which has been identified as a novel NTPase that binds NTP in a deep cleft similarly located to the conserved patch of surface residues that define an analogous cleft in VC0702. Collectively, the data suggest that VC0702 may have a biochemical function that involves NTP binding and phosphatase activity of some kind, and is likely involved in regulation of the signaling pathway that controls biofilm formation and maintenance in Vibrio cholerae.

About this Structure

1ZNO is a Single protein structure of sequence from Vibrio cholerae. Full crystallographic information is available from OCA.

Reference

Crystal structure of VC0702 at 2.0 A: conserved hypothetical protein from Vibrio cholerae., Ni S, Forouhar F, Bussiere DE, Robinson H, Kennedy MA, Proteins. 2006 Jun 1;63(4):733-41. PMID:16498616 Page seeded by OCA on Sat May 3 17:51:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools