1zoy

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[[Image:1zoy.gif|left|200px]]
[[Image:1zoy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zoy |SIZE=350|CAPTION= <scene name='initialview01'>1zoy</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1zoy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate_dehydrogenase_(ubiquinone) Succinate dehydrogenase (ubiquinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.1 1.3.5.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1zoy| PDB=1zoy | SCENE= }}
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|RELATEDENTRY=[[1zp0|1ZP0]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zoy OCA], [http://www.ebi.ac.uk/pdbsum/1zoy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zoy RCSB]</span>
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}}
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'''Crystal Structure of Mitochondrial Respiratory Complex II from porcine heart at 2.4 Angstroms'''
'''Crystal Structure of Mitochondrial Respiratory Complex II from porcine heart at 2.4 Angstroms'''
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==About this Structure==
==About this Structure==
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1ZOY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOY OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOY OCA].
==Reference==
==Reference==
Crystal structure of mitochondrial respiratory membrane protein complex II., Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z, Cell. 2005 Jul 1;121(7):1043-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15989954 15989954]
Crystal structure of mitochondrial respiratory membrane protein complex II., Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z, Cell. 2005 Jul 1;121(7):1043-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15989954 15989954]
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[[Category: Protein complex]]
 
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[[Category: Succinate dehydrogenase (ubiquinone)]]
 
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[[Category: Sus scrofa]]
 
[[Category: Bartlam, M.]]
[[Category: Bartlam, M.]]
[[Category: Huo, X.]]
[[Category: Huo, X.]]
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[[Category: Xu, J.]]
[[Category: Xu, J.]]
[[Category: Zhai, Y.]]
[[Category: Zhai, Y.]]
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[[Category: membrane protein structure]]
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[[Category: Membrane protein structure]]
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[[Category: mitochondrial respiratory complex ii]]
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[[Category: Mitochondrial respiratory complex ii]]
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[[Category: succinate]]
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[[Category: Succinate]]
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[[Category: ubiquinone oxidoreductase]]
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[[Category: Ubiquinone oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:53:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:39:46 2008''
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Revision as of 14:53, 3 May 2008

Image:1zoy.gif

Template:STRUCTURE 1zoy

Crystal Structure of Mitochondrial Respiratory Complex II from porcine heart at 2.4 Angstroms


Overview

The mitochondrial respiratory Complex II or succinate:ubiquinone oxidoreductase (SQR) is an integral membrane protein complex in both the tricarboxylic acid cycle and aerobic respiration. Here we report the first crystal structure of Complex II from porcine heart at 2.4 A resolution and its complex structure with inhibitors 3-nitropropionate and 2-thenoyltrifluoroacetone (TTFA) at 3.5 A resolution. Complex II is comprised of two hydrophilic proteins, flavoprotein (Fp) and iron-sulfur protein (Ip), and two transmembrane proteins (CybL and CybS), as well as prosthetic groups required for electron transfer from succinate to ubiquinone. The structure correlates the protein environments around prosthetic groups with their unique midpoint redox potentials. Two ubiquinone binding sites are discussed and elucidated by TTFA binding. The Complex II structure provides a bona fide model for study of the mitochondrial respiratory system and human mitochondrial diseases related to mutations in this complex.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of mitochondrial respiratory membrane protein complex II., Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z, Cell. 2005 Jul 1;121(7):1043-57. PMID:15989954 Page seeded by OCA on Sat May 3 17:53:47 2008

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