1ztp

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[[Image:1ztp.gif|left|200px]]
[[Image:1ztp.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ztp |SIZE=350|CAPTION= <scene name='initialview01'>1ztp</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1ztp", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= Hs.433573 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam08939 DUF1917]</span>
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{{STRUCTURE_1ztp| PDB=1ztp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ztp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ztp OCA], [http://www.ebi.ac.uk/pdbsum/1ztp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ztp RCSB]</span>
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'''X-ray structure of gene product from homo sapiens Hs.433573'''
'''X-ray structure of gene product from homo sapiens Hs.433573'''
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[[Category: Jr., G N.Phillips.]]
[[Category: Jr., G N.Phillips.]]
[[Category: Wesenberg, G E.]]
[[Category: Wesenberg, G E.]]
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[[Category: bc010512]]
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[[Category: Bc010512]]
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[[Category: bles03]]
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[[Category: Bles03]]
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[[Category: center for eukaryotic structural genomic]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: cesg]]
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[[Category: Cesg]]
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[[Category: hs 433573]]
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[[Category: Hs 433573]]
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[[Category: p5326]]
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[[Category: P5326]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi]]
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[[Category: Psi]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: unknown function]]
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[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:03:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:41:30 2008''
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Revision as of 15:03, 3 May 2008

Image:1ztp.gif

Template:STRUCTURE 1ztp

X-ray structure of gene product from homo sapiens Hs.433573


Overview

The crystal structure of the human basophilic leukemia-expressed protein (BLES03, p5326, Hs.433573) was determined by single-wavelength anomalous diffraction and refined to an R factor of 18.8% (Rfree = 24.5%) at 2.5 A resolution. BLES03 shows no detectable sequence similarity to any functionally characterized proteins using state-of-the-art sequence-comparison tools. The structure of BLES03 adopts a fold similar to that of eukaryotic transcription initiation factor 4E (eIF4E), a protein involved in the recognition of the cap structure of eukaryotic mRNA. In addition to fold similarity, the electrostatic surface potentials of BLES03 and eIF4E show a clear conservation of basic and acidic patches. In the crystal lattice, the acidic amino-terminal helices of BLES03 monomers are bound within the basic cavity of symmetry-related monomers in a manner analogous to the binding of mRNA by eIF4E. Interestingly, the gene locus encoding BLES03 is located between genes encoding the proteins DRAP1 and FOSL1, both of which are involved in transcription initiation. It is hypothesized that BLES03 itself may be involved in a biochemical process that requires recognition of nucleic acids.

About this Structure

1ZTP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure at 2.5 A resolution of human basophilic leukemia-expressed protein BLES03., Bitto E, Bingman CA, Robinson H, Allard ST, Wesenberg GE, Phillips GN Jr, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Sep 1;61(Pt, 9):812-7. Epub 2005 Aug 31. PMID:16511166 Page seeded by OCA on Sat May 3 18:03:43 2008

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OCA

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