1zv8

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[[Image:1zv8.gif|left|200px]]
[[Image:1zv8.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zv8 |SIZE=350|CAPTION= <scene name='initialview01'>1zv8</scene>, resolution 1.94&Aring;
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The line below this paragraph, containing "STRUCTURE_1zv8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human SARS coronavirus]), S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])
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-->
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|DOMAIN=
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{{STRUCTURE_1zv8| PDB=1zv8 | SCENE= }}
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|RELATEDENTRY=[[1zv7|1ZV7]], [[1zva|1ZVA]], [[1zvb|1ZVB]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zv8 OCA], [http://www.ebi.ac.uk/pdbsum/1zv8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zv8 RCSB]</span>
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}}
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'''A structure-based mechanism of SARS virus membrane fusion'''
'''A structure-based mechanism of SARS virus membrane fusion'''
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[[Category: Yong, W.]]
[[Category: Yong, W.]]
[[Category: Zheng, Q.]]
[[Category: Zheng, Q.]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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[[Category: conformational change]]
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[[Category: Conformational change]]
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[[Category: membrane fusion]]
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[[Category: Membrane fusion]]
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[[Category: s2]]
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[[Category: S2]]
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[[Category: sars coronavirus]]
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[[Category: Sars coronavirus]]
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[[Category: virus entry]]
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[[Category: Virus entry]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:06:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:42:06 2008''
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Revision as of 15:06, 3 May 2008

Image:1zv8.gif

Template:STRUCTURE 1zv8

A structure-based mechanism of SARS virus membrane fusion


Overview

Entry of SARS coronavirus into its target cell requires large-scale structural transitions in the viral spike (S) glycoprotein in order to induce fusion of the virus and cell membranes. Here we describe the identification and crystal structures of four distinct alpha-helical domains derived from the highly conserved heptad-repeat (HR) regions of the S2 fusion subunit. The four domains are an antiparallel four-stranded coiled coil, a parallel trimeric coiled coil, a four-helix bundle, and a six-helix bundle that is likely the final fusogenic form of the protein. When considered together, the structural and thermodynamic features of the four domains suggest a possible mechanism whereby the HR regions, initially sequestered in the native S glycoprotein spike, are released and refold sequentially to promote membrane fusion. Our results provide a structural framework for understanding the control of membrane fusion and should guide efforts to intervene in the SARS coronavirus entry process.

About this Structure

1ZV8 is a Protein complex structure of sequences from Human sars coronavirus and Sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein., Deng Y, Liu J, Zheng Q, Yong W, Lu M, Structure. 2006 May;14(5):889-99. PMID:16698550 Page seeded by OCA on Sat May 3 18:06:48 2008

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OCA

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