1zxk

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[[Image:1zxk.gif|left|200px]]
[[Image:1zxk.gif|left|200px]]
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{{Structure
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|PDB= 1zxk |SIZE=350|CAPTION= <scene name='initialview01'>1zxk</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1zxk", creates the "Structure Box" on the page.
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|SITE=
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|GENE= Cdh8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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{{STRUCTURE_1zxk| PDB=1zxk | SCENE= }}
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|RELATEDENTRY=[[1zvn|1ZVN]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxk OCA], [http://www.ebi.ac.uk/pdbsum/1zxk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zxk RCSB]</span>
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'''Crystal Structure of Cadherin8 EC1 domain'''
'''Crystal Structure of Cadherin8 EC1 domain'''
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[[Category: Schieren, I.]]
[[Category: Schieren, I.]]
[[Category: Shapiro, L.]]
[[Category: Shapiro, L.]]
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[[Category: cadherin]]
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[[Category: Cadherin]]
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[[Category: strand dimer]]
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[[Category: Strand dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:12:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:42:59 2008''
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Revision as of 15:12, 3 May 2008

Image:1zxk.gif

Template:STRUCTURE 1zxk

Crystal Structure of Cadherin8 EC1 domain


Overview

Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from three type II cadherins reveals adhesive dimers formed by exchange of N-terminal beta strands between partner extracellular cadherin-1 (EC1) domains. These interfaces have two conserved tryptophan side chains that anchor each swapped strand, compared with one in type I cadherins, and include large hydrophobic regions unique to type II interfaces. The EC1 domains of type I and type II cadherins appear to encode cell adhesive specificity in vitro. Moreover, perturbation of motor neuron segregation with chimeric cadherins depends on EC1 domain identity, suggesting that this region, which includes the structurally defined adhesive interface, encodes type II cadherin functional specificity in vivo.

About this Structure

1ZXK is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Type II cadherin ectodomain structures: implications for classical cadherin specificity., Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L, Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 Page seeded by OCA on Sat May 3 18:12:24 2008

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