1zy3
From Proteopedia
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[[Image:1zy3.gif|left|200px]] | [[Image:1zy3.gif|left|200px]] | ||
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'''Structural model of complex of Bcl-w protein with Bid BH3-peptide''' | '''Structural model of complex of Bcl-w protein with Bid BH3-peptide''' | ||
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[[Category: Denisov, A Y.]] | [[Category: Denisov, A Y.]] | ||
[[Category: Gehring, K.]] | [[Category: Gehring, K.]] | ||
| - | [[Category: | + | [[Category: Apoptosis]] |
| - | [[Category: | + | [[Category: Bcl-w]] |
| - | [[Category: | + | [[Category: Bh3-peptide]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:13:26 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 15:13, 3 May 2008
Structural model of complex of Bcl-w protein with Bid BH3-peptide
Overview
A peptide corresponding to the BH3 region of the proapoptotic protein, BID, could be bound in the cleft of the antiapoptotic protein, BCL-w. This binding induced major conformational rearrangements in both the peptide and protein components of the complex and led to the displacement and unfolding of the BCL-w C-terminal alpha-helix. The structure of BCL-w with a bound BID-BH3 peptide was determined using NMR spectroscopy and molecular docking. These studies confirmed that a region of 16 residues of the BID-BH3 peptide is responsible for its strong binding to BCL-w and BCL-x(L). The interactions of BCL-w and the BID-BH3 peptide complex with dodecylphosphocholine micelles were characterized and showed that the conformational change of BCL-w upon lipid binding occurred at the same time as the release and unfolding of the BH3 peptide.
About this Structure
1ZY3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles., Denisov AY, Chen G, Sprules T, Moldoveanu T, Beauparlant P, Gehring K, Biochemistry. 2006 Feb 21;45(7):2250-6. PMID:16475813 Page seeded by OCA on Sat May 3 18:13:26 2008
