1zz7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1zz7.gif|left|200px]]
[[Image:1zz7.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1zz7 |SIZE=350|CAPTION= <scene name='initialview01'>1zz7</scene>, resolution 2.10&Aring;
+
The line below this paragraph, containing "STRUCTURE_1zz7", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=S0H:(S)-2-HYDROXYPROPYLPHOSPHONIC+ACID'>S0H</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= fom4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=43759 Streptomyces wedmorensis])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1zz7| PDB=1zz7 | SCENE= }}
-
|RELATEDENTRY=[[1zz6|1ZZ6]], [[1zz8|1ZZ8]], [[1zz9|1ZZ9]], [[1zzb|1ZZB]], [[1zzc|1ZZC]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zz7 OCA], [http://www.ebi.ac.uk/pdbsum/1zz7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zz7 RCSB]</span>
+
-
}}
+
'''Crystal Structure of FeII HppE in Complex with Substrate form 1'''
'''Crystal Structure of FeII HppE in Complex with Substrate form 1'''
Line 30: Line 27:
[[Category: Liu, P.]]
[[Category: Liu, P.]]
[[Category: Yan, F.]]
[[Category: Yan, F.]]
-
[[Category: cupin]]
+
[[Category: Cupin]]
-
[[Category: mononuclear iron enzyme]]
+
[[Category: Mononuclear iron enzyme]]
-
[[Category: substrate-enzyme complex]]
+
[[Category: Substrate-enzyme complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:15:46 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:43:35 2008''
+

Revision as of 15:15, 3 May 2008

Image:1zz7.gif

Template:STRUCTURE 1zz7

Crystal Structure of FeII HppE in Complex with Substrate form 1


Overview

The biosynthetic pathway of the clinically important antibiotic fosfomycin uses enzymes that catalyse reactions without precedent in biology. Among these is hydroxypropylphosphonic acid epoxidase, which represents a new subfamily of non-haem mononuclear iron enzymes. Here we present six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution; a native Fe(II)-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co(II)-enzyme complex structure at 1.8 A resolution; a substrate-Co(II)-enzyme complex structure at 2.5 A resolution; and two substrate-Fe(II)-enzyme complexes at 2.1 and 2.3 A resolution. These structural data lead us to suggest how this enzyme is able to recognize and respond to its substrate with a conformational change that protects the radical-based intermediates formed during catalysis. Comparisons with other family members suggest why substrate binding is able to prime iron for dioxygen binding in the absence of alpha-ketoglutarate (a co-substrate required by many mononuclear iron enzymes), and how the unique epoxidation reaction of hydroxypropylphosphonic acid epoxidase may occur.

About this Structure

1ZZ7 is a Single protein structure of sequence from Streptomyces wedmorensis. Full crystallographic information is available from OCA.

Reference

Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme., Higgins LJ, Yan F, Liu P, Liu HW, Drennan CL, Nature. 2005 Oct 6;437(7060):838-44. Epub 2005 Jul 13. PMID:16015285 Page seeded by OCA on Sat May 3 18:15:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zz7"
Personal tools