1zzw

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[[Image:1zzw.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zzw OCA], [http://www.ebi.ac.uk/pdbsum/1zzw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zzw RCSB]</span>
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'''Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5'''
'''Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5'''
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[[Category: Son, J H.]]
[[Category: Son, J H.]]
[[Category: Yoon, T S.]]
[[Category: Yoon, T S.]]
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[[Category: mkp]]
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[[Category: Mkp]]
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[[Category: phosphatase]]
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[[Category: Phosphatase]]
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[[Category: ptp]]
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[[Category: Ptp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:17:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:43:56 2008''
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Revision as of 15:17, 3 May 2008

Image:1zzw.gif

Template:STRUCTURE 1zzw

Crystal Structure of catalytic domain of Human MAP Kinase Phosphatase 5


Overview

MAP kinase phosphatase 5 (MKP5) is a member of the mitogen-activated protein kinase phosphatase (MKP) family and selectively dephosphorylates JNK and p38. We have determined the crystal structure of the catalytic domain of human MKP5 (MKP5-C) to 1.6 A. In previously reported MKP-C structures, the residues that constitute the active site are seriously deviated from the active conformation of protein tyrosine phosphatases (PTPs), which are accompanied by low catalytic activity. High activities of MKPs are achieved by binding their cognate substrates, representing substrate-induced activation. However, the MKP5-C structure adopts an active conformation of PTP even in the absence of its substrate binding, which is consistent with the previous results that MKP5 solely possesses the intrinsic activity. Further, we identify a sequence motif common to the members of MKPs having low catalytic activity by comparing structures and sequences of other MKPs. Our structural information provides an explanation of constitutive activity of MKP5 as well as the structural insight into substrate-induced activation occurred in other MKPs.

About this Structure

1ZZW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase., Jeong DG, Yoon TS, Kim JH, Shim MY, Jung SK, Son JH, Ryu SE, Kim SJ, J Mol Biol. 2006 Jul 28;360(5):946-55. Epub 2006 Jun 9. PMID:16806267 Page seeded by OCA on Sat May 3 18:17:27 2008

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