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208d
From Proteopedia
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[[Image:208d.gif|left|200px]] | [[Image:208d.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_208d| PDB=208d | SCENE= }} | |
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'''HIGH-RESOLUTION STRUCTURE OF A DNA HELIX FORMING (C.G)*G BASE TRIPLETS''' | '''HIGH-RESOLUTION STRUCTURE OF A DNA HELIX FORMING (C.G)*G BASE TRIPLETS''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=208D OCA]. | |
==Reference== | ==Reference== | ||
High-resolution structure of a DNA helix forming (C.G)*G base triplets., Van Meervelt L, Vlieghe D, Dautant A, Gallois B, Precigoux G, Kennard O, Nature. 1995 Apr 20;374(6524):742-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7715732 7715732] | High-resolution structure of a DNA helix forming (C.G)*G base triplets., Van Meervelt L, Vlieghe D, Dautant A, Gallois B, Precigoux G, Kennard O, Nature. 1995 Apr 20;374(6524):742-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7715732 7715732] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Dautant, A.]] | [[Category: Dautant, A.]] | ||
[[Category: Gallois, B.]] | [[Category: Gallois, B.]] | ||
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[[Category: Precigoux, G.]] | [[Category: Precigoux, G.]] | ||
[[Category: Vlieghe, D.]] | [[Category: Vlieghe, D.]] | ||
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| - | [[Category: | + | [[Category: Base triplet]] |
| - | [[Category: | + | [[Category: Double helix]] |
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Revision as of 15:18, 3 May 2008
HIGH-RESOLUTION STRUCTURE OF A DNA HELIX FORMING (C.G)*G BASE TRIPLETS
Overview
Triple helices result from interaction between single- and double-stranded nucleic acids. Their formation is a possible mechanism for recombination of homologous gene sequences in nature and provides, inter alia, a basis for artificial control of gene activity. Triple-helix motifs have been extensively studied by a variety of techniques, but few high-resolution structural data are available. The only triplet structures characterized so far by X-ray diffraction were in protein-DNA complexes studied at about 3 A resolution. We report here the X-ray analysis of a DNA nonamer, d(GCGAATTCG), to a resolution of 2.05 A, in which the extended crystal structure contains (C.G)*G triplets as a fragment of triple helix. The guanosine-containing chains are in a parallel orientation. This arrangement is a necessary feature of models for homologous recombination which results ultimately in replacement of one length of DNA by another of similar sequence. The present-structure agrees with many published predictions of triplex organization, and provides an accurate representation of an element that allows sequence-specific association between single- and double-stranded nucleic acids.
About this Structure
Full crystallographic information is available from OCA.
Reference
High-resolution structure of a DNA helix forming (C.G)*G base triplets., Van Meervelt L, Vlieghe D, Dautant A, Gallois B, Precigoux G, Kennard O, Nature. 1995 Apr 20;374(6524):742-4. PMID:7715732 Page seeded by OCA on Sat May 3 18:18:11 2008
