2a0t

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[[Image:2a0t.gif|left|200px]]
[[Image:2a0t.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2a0t |SIZE=350|CAPTION= <scene name='initialview01'>2a0t</scene>
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The line below this paragraph, containing "STRUCTURE_2a0t", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= SPK1 or Rad53 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_2a0t| PDB=2a0t | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a0t OCA], [http://www.ebi.ac.uk/pdbsum/2a0t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a0t RCSB]</span>
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}}
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'''NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1'''
'''NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1'''
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[[Category: Tsai, M D.]]
[[Category: Tsai, M D.]]
[[Category: Yuan, C.]]
[[Category: Yuan, C.]]
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[[Category: fha domain. rad53]]
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[[Category: Fha domain. rad53]]
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[[Category: mdt1]]
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[[Category: Mdt1]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: phosphoprotein]]
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[[Category: Phosphoprotein]]
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[[Category: phosphothreonine]]
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[[Category: Phosphothreonine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:27:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:46:21 2008''
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Revision as of 15:27, 3 May 2008

Image:2a0t.gif

Template:STRUCTURE 2a0t

NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1


Overview

Combinatorial library screens based on binding affinity may preferentially select ligands with ability for ionic interactions and miss the biologically relevant ligands that bind more weakly with predominantly hydrophobic interactions.

About this Structure

2A0T is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

FHA domain-ligand interactions: importance of integrating chemical and biological approaches., Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD, J Am Chem Soc. 2005 Oct 26;127(42):14572-3. PMID:16231900 Page seeded by OCA on Sat May 3 18:27:55 2008

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OCA

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