2a0z

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[[Image:2a0z.gif|left|200px]]
[[Image:2a0z.gif|left|200px]]
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{{Structure
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|PDB= 2a0z |SIZE=350|CAPTION= <scene name='initialview01'>2a0z</scene>, resolution 2.400&Aring;
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The line below this paragraph, containing "STRUCTURE_2a0z", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_2a0z| PDB=2a0z | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a0z OCA], [http://www.ebi.ac.uk/pdbsum/2a0z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a0z RCSB]</span>
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'''The molecular structure of toll-like receptor 3 ligand binding domain'''
'''The molecular structure of toll-like receptor 3 ligand binding domain'''
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[[Category: Segal, D M.]]
[[Category: Segal, D M.]]
[[Category: Shiloach, J.]]
[[Category: Shiloach, J.]]
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[[Category: glycosylation]]
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[[Category: Glycosylation]]
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[[Category: leucine rich repeat]]
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[[Category: Leucine rich repeat]]
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[[Category: solenoid]]
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[[Category: Solenoid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:28:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:46:23 2008''
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Revision as of 15:28, 3 May 2008

Image:2a0z.gif

Template:STRUCTURE 2a0z

The molecular structure of toll-like receptor 3 ligand binding domain


Overview

Innate immunity is the first line of defense against invading pathogens. Toll-like receptors (TLRs) act as sentinels of the innate immune system, sensing a variety of ligands from lipopolysaccharide to flagellin to dsRNA through their ligand-binding domain that is composed of leucine-rich repeats (LRRs). Ligand binding initiates a signaling cascade that leads to the up-regulation of inflammation mediators. In this study, we have expressed and crystallized the ectodomain (ECD) of human TLR3, which recognizes dsRNA, a molecular signature of viruses, and have determined the molecular structure to 2.4-A resolution. The overall horseshoe-shaped structure of the TLR3-ECD is formed by 23 repeating LRRs that are capped at each end by specialized non-LRR domains. The extensive beta-sheet on the molecule's concave surface forms a platform for several modifications, including insertions in the LRRs and 11 N-linked glycans. The TLR3-ECD structure indicates how LRR loops can establish distinct pathogen recognition receptors.

About this Structure

2A0Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The molecular structure of the Toll-like receptor 3 ligand-binding domain., Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal DM, Davies DR, Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10976-80. Epub 2005 Jul 25. PMID:16043704 Page seeded by OCA on Sat May 3 18:28:17 2008

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