2a11

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[[Image:2a11.gif|left|200px]]
[[Image:2a11.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2a11 |SIZE=350|CAPTION= <scene name='initialview01'>2a11</scene>, resolution 2.100&Aring;
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The line below this paragraph, containing "STRUCTURE_2a11", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_III Ribonuclease III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.3 3.1.26.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= rnc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00048 DSRM], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00593 RIBOc], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK00102 rnc]</span>
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{{STRUCTURE_2a11| PDB=2a11 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a11 OCA], [http://www.ebi.ac.uk/pdbsum/2a11 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a11 RCSB]</span>
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'''Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis'''
'''Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis'''
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[[Category: Berger, J M.]]
[[Category: Berger, J M.]]
[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]]
[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]]
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[[Category: mycobacterium tuberculosis structural proteomics project (xmtb)]]
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[[Category: Nuclease domain]]
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[[Category: nuclease domain]]
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[[Category: Protein structure initiative]]
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[[Category: protein structure initiative]]
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[[Category: Psi]]
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[[Category: psi]]
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[[Category: Ribonuclease]]
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[[Category: ribonuclease]]
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[[Category: Rnase iii]]
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[[Category: rnase iii]]
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[[Category: Structural genomic]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:28:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:46:27 2008''
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Revision as of 15:28, 3 May 2008

Image:2a11.gif

Template:STRUCTURE 2a11

Crystal Structure of Nuclease Domain of Ribonuclase III from Mycobacterium Tuberculosis


Overview

RNase III enzymes are a highly conserved family of proteins that specifically cleave double-stranded (ds)RNA. These proteins are involved in a diverse group of functions, including ribosomal RNA processing, mRNA maturation and decay, snRNA and snoRNA processing, and RNA interference. Here we report the crystal structure of the nuclease domain of RNase III from the pathogen Mycobacterium tuberculosis. Although globally similar to other RNase III folds, this structure has some features not observed in previously reported models. These include the presence of an additional metal ion near the catalytic site, as well as conserved secondary structural elements that are proposed to have functional roles in the recognition of dsRNAs.

About this Structure

2A11 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Structure of the nuclease domain of ribonuclease III from M. tuberculosis at 2.1 A., Akey DL, Berger JM, Protein Sci. 2005 Oct;14(10):2744-50. Epub 2005 Sep 9. PMID:16155207 Page seeded by OCA on Sat May 3 18:28:19 2008

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